Abstract
Background: pancytopenia is defined as the simultaneous existence of anemia, leukopenia, thrombocytopenia. It is encountered in day to day clinical practice. Knowing the underlying cause determines the appropriate management. The aim of the study was to obtain the common causes causing pancytopenia in patients admitted in tertiary care hospital in north Andhra and the frequency of various etiological factors.
Materials and Methods: This prospective observational study was done in the department of general medicine in tertiary hospital over 7 months period from January 2020 to July 2020. History, blood investigations, the peripheral smear was done for all patients and bone marrow examination was done for selected patients.
Results: out of 100 patients 61 were male and 39 were female. Megaloblastic anemia was the commonest cause that was observed followed by aplastic anemia, chronic liver disease, haematological malignancy, infections like HIV and malaria, SLE.
Conclusion: The most common cause of pancytopenia in this part of India is megaloblastic anemia which is a curable deficiency.
Keywords: pancytopenia, megaloblastic anemia, aplastic anemia.
References
- Khodke K, Marwah S, Buxi G, Yadav RB, Chaturvedi NK. Bone marrow examination in case of pancytopenia. J Indian Aca Clin Med 2001; 2:55-9.
- Tilak V, Jain Pancytopenia - a clinic hematologic analysis of 77 cases. Indian J Pathol Microbiol 1999;42:399-404
- Gayathri BN, Rao Pancytopenia: A clinicohematological study. J Lab Physicians 2011; 3:15-20.
- Raphael V, Khonglah Y , Dey B, Gogoi P, Bhuyan A, et Pancytopenia: An Etiological Profile. Turk J Hematol 2012; 29: 80-81.
- Dasgupta S, Mandal PK, Chakrabarti Etiology of Pancytopenia: An observation from a referral medical institution of Eastern Region of India. J Lab Physicians 2015; 7:90-5.
- Azaad MA, Li YP, Zhang QR and Wang Detection of Pancytopenia Associated with Clinical Manifestation and Their Final Diagnosis. Open Journal of Blood Diseases 2015; 5:17-30.
- Jain A, Naniwadekar An etiological reappraisal of pancytopenia – Largest series reported to date from a single tertiary care teaching hospital. BMC Hematol 2013; 13:10.
- Study of Pancytopenia in a Tertiary Care Hospital in North Karnataka Kulkarni Naveen S*, Patil Appu S, and Karchi SD General Medicine, S. Nijalingappa Medical College and H. S. K. Hospital & Research Centre, Navanagar Bagalkot, Karnataka, India.
- The Common Causes Leading to Pancytopenia in Patients Presenting in Hospital of Central India T. N. Dubey1, Preeti Nigotia2, Rita Saxena3
- Suryaresmi BS, Abraham L, Mathew A, Raj JM. The etiological spectrum of pancytopenia diagnosed from blood smears examined in the pathology department of a rural tertiary care centre in South India. Int J Med Sci Public Health 2018;7(2):126-131.
- Etiological and clinical spectrum of pancytopenia based on bone marrow examination and case records: A retrospective study Prashanth B Gandhi1, Tharanath Shankar1, Mohammed \Afraz Pasha2*, Mangala Gouri.
Corresponding Author
Dr Marri Lakshmi Harika
Post Graduate, Department of General Medicine
King George Hospital
DOI: https://dx.doi.org/10.18535/jmscr/v8i8.45
