Abstract
Low back pain is extremely prevalent, it is the most common presenting complaint in neurosurgery clinic. Regardless of the underlying cause, organic or inorganic low back pain has it's financial impact on patients , hospitals ,and work resources.
This study was designed to discuss causes of low back pain, address the effectiveness of different Non-steroidal Anti-inflammatory Medications on acute low back pain, regardless of the underlying aetiology, assess paracetamol and muscle relaxants effect compared to NSAID, and discuss cost-benefit effect of different medications used in LBP.
Patients prescribed with diclofenac 150 mg, celecoxib 200 mg, Etoricoxib 90 mg, or combination of Paracetamol 1500mg + Chlorzoxazone 1500mg, "daily" for acute low back pain at Neurosurgery Outpatients Department, were enrolled in this study. The decrease in pain scores was recorded on 5th and 10th days of follow-up and pain scores were calculated. Descriptive statistics were used for analysis.
All medications used in this study were equally successful in short term symptom relief and dramatically reducing pain, and no drug was found to be superior. This clearly indicates equal effectiveness of medications used and homogenously and carefully selected study sample.
Keywords: low back pain, non-steroidal Anti-inflammatory Drugs (NSAID).
References
- Mark S. Greenberg Seventh Edition, page 428
- Greenburg 7th edition page 428
- Motion preservation Surgery of the Spine Page 760
- © 2000 Lippincott Williams & Wilkins, Inc.
- This trial was registered with the Australian Clinical Trials Registry, ACTRN012605000036617.
- http://www.cochrane.org/CD012382/BACK_non-steroidal-anti-inflammatory-drugs-low-back-pain-sciatica
- https://www.ncbi.nlm.nih.gov/pubmed/10796356
- https://www.medscape.org/viewarticle/569247
- https://www.medscape.org/viewarticle/572783
- Andersson GBJ. The epidemiology of spinal disorders. In: Frymoyer JW, Ducker TB, Hadler NM, Kostuik JP, Weinstein JN, Whitecloud TS, editors.The Adult Spine: Principles and Practice. Philadelphia, PA: Lippincott-Raven; 1997. pp. 93–141.
- Cassidy JD, Carroll LJ, Cote P. The Saskatchewan health and back pain survey. The prevalence of low back pain and related disability in Saskatchewan adults. 1998;23:1860–7. [PubMed]
- Leboeuf-Yde C, Lauritsen JM. The prevalence of low back in the literature: A structured review of 26 Nordic studies from 1954 to 1993. 1995;20:2112–28. [PubMed]
- Whitecloud TS, editors.The Adult Spine: Principles and Practice. Philadelphia, PA: Lippincott-Raven; 1997. pp. 143–50.
- Hart LG, Deyo RA, Cherkin DC. Physician office visits for low back pain. Frequency, clinical evaluation, and treatment patterns from a U.S. national survey. 1995;20:11–9. [PubMed]
- Cypress BK. Characteristics of physician visits for back symptoms: A national perspective.Am J Public Health.1983;73:389–95. [PMC free article] [PubMed]
- Carey TS, Evans AT, Hadler NM, et al. Acute severe low back pain. A population-based study of prevalence and care-seeking. 1996;21:339–44. [PubMed]
- Coste J, Delecoeuillerie G, Cohen de Lara A, Le Parc JM, Paolaggi JB. Clinical course and prognostic factors in acute low back pain: an inception cohort study in primary care practice. 1994;308:577–80.[PMC free article] [PubMed]
- Kelsey JL.Epidemiology of musculoskeletal disorders. New York, NY: Oxford University Press; 1992.
- Cherkin DC, Deyo RA, Street JH, Barlow W. Predicting poor outcomes for back pain seen in primary care using patients' own criteria. 1996;21:2900–7. [PubMed]
- Croft PR, Macfarlane GJ, Papageorgiou AC, Thomas E, Silman AJ. Outcome of low back pain in general practice: a prospective study. 1998;316:1356–9. [PMC free article] [PubMed]
- van den Hoogen HJ, Koes BW, van Eijk JT, Bouter LM, Deville W. On the course of low back pain in general practice: a one year follow up study.Ann Rheum Dis. 1998;57:13–9. [PMC free article] [PubMed]
- Von Korff M, Saunders K. The course of back pain in primary care. 1996;21:2833–7. [PubMed]
- Von Korff M, Deyo RA, Cherkin D, Barlow W. Back pain in primary care. Outcomes at 1 year.1993;18:855–62. [PubMed]
Corresponding Author
Dr Naded Y.H. Albatta