Title: Possible role of Cold Agglutinins in Pathogenesis of Acquired Autoimmune Hemolytic Anemia
Authors: AK Kapoor, Pratishtha Rastogi, Akanksha Singh, Surbhi Rajauria, Divya Saxena, Surabhi Maheshwari
DOI: https://dx.doi.org/10.18535/jmscr/v6i3.137
Abstract
Present study relates to the results of detection of high-titer cold anti I antibodies in sera of 3 patients with anemia. Age of the patients ranged from 15 to 67 (median 30) years. Characterization of immune complexes on sensitized erythrocytes revealed presence of IgM, IgG1, IgG3, IgA, C3c and C3d in a patient, suggesting a diagnosis of cold agglutinin disease (CAD). Another case had IgG1, IgG3, IgA, C3c and C3d, suggesting a diagnosis of paroxysmal cold hemoglobinuria (PCH). Another patient had C3d alone on their erythrocytes, suggesting dissociation of immunoglobulins from red cell membranes. Findings of this study suggest possible role of cold agglutinins in pathogenesis of autoimmune hemolytic anemia.
Keywords: Heterophil anti I antibody, IgM, IgG.
