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Category: Volume 07 Issue 12 December 2019
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Title: Role of Mirabegron in the Treatment of Overactive Bladder: A Prospective Study

Authors: Dr Gurpreet Singh Bhangu, Dr Ritansh Bansal, Dr Darpan Bansal, Dr Ripudaman Singh, Dr Amrik Singh Bhatia

 DOI: https://dx.doi.org/10.18535/jmscr/v7i12.09

Abstract

Introduction

Overactive bladder (also known as OAB or OAB Syndrome) is defined as a medical condition having the symptoms of urinary frequency (>8 micturitions/24 hours), urgency with a difficulty to defer and nocturia with or without urge incontinence, in the absence of local pathological or metabolic factors that would account for these symptoms.1 These symptoms even in the absence of incontinence can have profound and stigmatizing effect on quality of life. However, they are under-reported by a majority of patients in lieu of the mis-beliefs such as incontinence is normal post-partum and with elderly age.2

The international continence society (ICS) has suggested OAB to be a urodynamic diagnosis of Detrusor Over activity (DO).  ICS defines this as an involuntary rise in detrusor pressure during filling of the bladder in a laboratory situation in a conscious co-operative patient.

Urinary frequency can be reliably measured by the maintenance of a voiding diary. Conventionally, up to seven micturition episodes during waking hours has been considered normal,4 but this number isn’t a constant and varies based upon hours of sleep, fluid intake, comorbid medical conditions and several other factors.

Urgency is defined by International Continence Society as the "complaint of a sudden, compelling desire to pass urine which is difficult to defer."5 It is considered to be the hallmark symptom of OAB, however it is difficult to define it for research or clinical purposes.

Nocturia is the complaint of interruption of sleep one or more times because of the need to void.5 

Urge incontinence is defined as the involuntary leakage of urine, associated with a sudden compelling desire to void.6 Incontinence episodes can be measured reliably with a diary, and the quantity of urine leakage can be measured with pad tests.

References

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Corresponding Author

Dr Darpan Bansal

Department of General Surgery, Sri Guru Ram Das Institute of Health Sciences and Research, Amritsar