Details
Category: Volume 13 Issue 05 May 2025
Hits: 3

Title: Irritable Bowel Syndrome (IBS): Pathophysiology, Diagnosis, and Management Strategies

Authors: Dr Ali Raj Azhar, Dr Ghazi Mir Jamal Uddin Bin Salam, Dr Manahil Rana

 DOI: https://dx.doi.org/10.18535/jmscr/v13i05.01

Abstract

Irritable bowel syndrome (IBS) is a prevalent gastrointestinal disorder characterized by a constellation of symptoms including chronic abdominal pain and altered bowel habit. IBS significantly affects patients' quality of life and presents a considerable economic burden on healthcare systems globally. This manuscript reviews the current understanding of IBS pathophysiology, diagnostic criteria, and management approaches.

References

  1. Chey, W. D., Kurlander, J., & Eswaran, S. (2015). Irritable bowel syndrome: a clinical review. JAMA, 313(9), 949-958. DOI: 10.1001/jama.2015.0954
  2. Ford, A. C., Sperber, A. D., Corsetti, M., & Camilleri, M. (2020). Irritable bowel syndrome.
    The Lancet, 396(10263), 1675-1688. DOI: 10.1016/S0140-6736(20)31548-8
  3. Ford, A. C., Lacy, B. E., & Harris, L. A. (2019). Effect of antidepressants and psychological therapies, including hypnotherapy, in irritable bowel syndrome: systematic review and meta-analysis.
  4. American Journal of Gastroenterology, 114(1), 21-39. DOI: 10.1038/s41395-018-0222-5
  5. Henström, M., & D’Amato, M. (2016). Genetics of irritable bowel syndrome.
  6. Molecular and Cellular Pediatrics, 3(1), 7. DOI: 10.1186/s40348-016-0038-6
  7. Ianiro, G., Eusebi, L. H., & Black, C. J. (2019). Systematic review with meta-analysis: efficacy of faecal microbiota transplantation for the treatment of irritable bowel syndrome. Alimentary Pharmacology & Therapeutics, 50(3), 240-248. DOI: 10.1111/apt.15330
  8. Lacy, B. E., Mearin, F., Chang, L., Chey, W. D., Lembo, A. J., Simren, M., & Spiller, R. (2016). Bowel disorders. Gastroenterology, 150(6), 1393-1407. DOI: 10.1053/j.gastro.2016.02.031
  9. Mayer, E. A., Labus, J. S., Tillisch, K., Cole, S. W., & Baldi, P. (2019). Towards a systems view of IBS. Nature Reviews Gastroenterology & Hepatology, 16(10), 592-605. DOI: 10.1038/s41575-019-0184-8
  10. Pimentel, M., Lembo, A., & Chey, W. D. (2021). Rifaximin therapy for patients with irritable bowel syndrome without constipation. New England Journal of Medicine, 364(1), 22-32. DOI: 10.1056/NEJMoa1004409
  11. Simrén, M., Tack, J., & Aziz, Q. (2019). Irritable bowel syndrome: pathogenesis, diagnosis and management. Nature Reviews Gastroenterology & Hepatology, 16(5), 275-286. DOI: 10.1038/s41575-019-0102-2
  12. Staudacher, H. M., Mikocka-Walus, A., Ford, A. C., & Gibson, P. R. (2020). Common mental disorders and IBS: impact of psychological therapies. Nature Reviews Gastroenterology & Hepatology, 17(6), 345-360. DOI: 10.1038/s41575-020-0295-z

Corresponding Author

Dr Ali Raj Azhar

MBChB MRCGP, Consultant Family Physician, Al Thumama Health Centre, Doha, Qatar