Title: The significance of CD1d expression in diagnosis of chronic lymphocytic leukemia and its value as a prognostic marker
Authors: Dahlia Ahmed El Sewefy, Gehan Mostafa Hamed
DOI: http://dx.doi.org/10.18535/jmscr/v4i2.56
Abstract
Back ground Chronic lymphocytic leukemia (CLL) is the most common type of leukemia in adults, its clinical course is highly heterogeneous. Proper diagnosis and discrimination of CLL from other B-chronic lymphoproliferative disorders (B-CLPDs), as well as prediction of disease outcome are very helpful in patient management and therapeutic decision-making.
Methods CD1d expression was measured in 43 newly diagnosed B-CLPDs patients including: 20 CLL, 10 MCL and 13 other B-CLPDs, and 10 age- and sex- matched controls.
Results Median CD1d % expression in CLL patients (16% [IQR; 9-31]) was significantly lower than normal controls and B-CLPDs (p<0.001). CD1d cut off value <38% can differentiate CLL from MCL and other B-CLPDs with high sensitivity and specificity. CD1d expression was significantly higher in CLL patients with advanced Rai stages (p<0.001), high CD38 expression (31 [20-35] versus, 9 [7.5=12]; p<0.001), poor cytogenetic abnormalities compared with CLL patients without poor cytogenetic abnormalities (15 [8.2 - 32 ] versus, 7.3 [2 - 16.6]; p=0.038).
Conclusion CD1d is a useful diagnostic marker that can differentiate CLL from MCL and other B-CLPDs. Higher CD1d expression in CLL is associated with poor prognosis and can define a subpopulation with more aggressive disease.
Key words CD1d, CLL, Diagnosis, prognostic marker.
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