Title: Mixed Connective Tissue Disorder Presenting As Eclampsia In A Primigravida: A Case Report
Authors: Dr Ankita Singh, Dr Sanjeev Behera, Prof Dr K.B.Subudhi
DOI: http://dx.doi.org/10.18535/jmscr/v4i4.40
Abstract
A 23 year old primigravida was diagnosed as a case of Mixed Connective Tissue Disorder (MCTD) after she presented with petechie, synovitis and raynauds phenomenon in the first trimester of pregnancy and was treated with steroids. In the third trimester she presented with Eclampsia and was treated with antihypertensives and magnesium sulphate. She delivered vaginally a live preterm child and was discharged healthy along with her baby.
Keyword: Mixed Connective Tissue Disorder (MCTD), ribonucleoprotein (RNP), ANA , Eclampsia
References
1. G Narsimulu, Varaprasad, mixed connective tissue disorder, Medicine Update 2010;Vol.20,17:8,841-45.
2. Sharp GC, Irvin WS, Tan EM, et al. Mixed connective tissue disease--an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA). Am J Med 1972; 52:148
3. Yildirim A, Tunaoolu FS, Karaaoac AT. Neonatal Indian Pediatr. 2013 May 8; 50 (5):483-8. Chakravarty EF, Khanna D, Chung L. Pregnancy outcomes in systemic sclerosis, primary pulmonary hypertension, and sickle cell disease. Obstet Gynecol. 2008 Apr; 111 (4):927-34.
4. Nakae, K, Furusawa, F, Kasukawa, R, et al. A nationwide epidemiological survey on diffuse collagen diseases: Estimation of prevalence rate in Japan. In: Mixed Connective Tissue Disease and Anti-nuclear Antibodies, Kasukawa, R, Sharp, G (Eds), Excerpta Medica, Amsterdam, 1987. p.9
5. Bennett, RM, O’Connell, D. Mixed connective tissue disease. A clinicopathological study of 20 cases. Semin Arthritis Rheum 1980; 10:25
6. A.TINCANI,M. NUZZO,M. MOTTA,A. LOJACONO;Autoimmune diseases and pregnancy; [haematologica reports]2006;2(10):56-60
7. Kaufman RL, Kitridou RC. Pregnancy in mixed connective tissue disease: comparison w ith systemic lupus erythematosus. J Rheumatol. 1982 Jul-Aug; 9(4):549-55.
8. Behluli I, Riehl J, Rath W. Mixed connective tissue disease and HELLP syndrome in pregnancy. Dtsch Med Wochenschr. 2007 Apr 20; 132(16):878-80.
9. Chung L, Flyckt RL, Colón I, Shah AA, Druzin M, Chakravarty EF. Outcome of pregnancies complicated by systemic sclerosis and mixed connective tissue disease. Lupus 2006; 15(9): 595-9.
10. Schulz SW, Bober M, Johnson C, Braverman N, Jimenez SA. Maternal mixed connective tissue disease and offspring w ith chondrodysplasia punctata. Semin Arthritis Rheum. 2010 Apr;39 (5):410-6. doi: 10.1016/j.semarthrit.2008.10.003. E pub 2008 Dec 24.