Title: Evaluation of Serum Apo B and A-I as Cardiac Biomarkers in Young Adult Population
Authors: Jabeen Fatima, Anees Syyeda, Sudha Bala
DOI: http://dx.doi.org/10.18535/jmscr/v4i6.55
Abstract
Clinically normal young adults with no well-known risk factors may present with metabolic syndrome, hypertension, atherogenic dyslipidemia and type-II diabetes. Age and sex are two non-modifiable risk factors for developing cardiovascular disturbances which may affect the levels of apolipoprotein B and apolipoprotein A-I.
The objective is to study serum apo B and A-I levels in association with the conventional lipid profile parameters in atherogenic dyslipidemia.
In this hospital-based prospective study, clinically normal males (n=172) and females (n=188), aged between 20-39 years, divided into two age groups: group-I (20-29 years) and group-II (30-39 years), subjected to overnight fasting had their lipid profile parameters (enzymatic colorimetric assay) along with the serum levels of apoB and apoA-I (immunoturbidimetry method) estimated. Subjects with body mass index (BMI) >30 were excluded from the study. Data was statistically analysed using Chi-square test and ROC curves.
ApoB levels showed continuous increase with age in both sexes with males having significantly raised (p<0.01) levels in both groups compared to females. ApoA-I levels declined with increasing age in both sexes and this decline was relatively earlier in males. Within each group females were having relatively raised (p<0.05) apoA-I levels than males. Moderate to strong correlations were observed between serum apoA-I and HDL-C concentrations (p<0.0001) and between serum apoB and LDL-C concentrations (p<0.0001), respectively.
ApoB may be a more sensitive measure of atherogenic dyslipidemia than LDL-C and a better index for assessing cardiovascular risk, whereas apoA-I did not add significantly to the estimation of future atherosclerotic vascular risk.
Keywords- ApoA-I, ApoB, Cardiovascular risk, Dyslipidemia, Lipid profile.
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