Title: Clinical Pregnancy Rate in Intra Uterine Insemination (IUI) is not Affected by the type of Catheter Used
Authors: Ashraf Hany Abdelrahman, HadeerAly Abbassy
DOI: https://dx.doi.org/10.18535/jmscr/v4i12.77
Abstract
Objective: To compare the clinical pregnancy rate of IUI with the Gynetics catheter (Gynetics Medical Products, Hamont-Achel, Belgium) or the Labotect catheter (labotect insemination catheter, Germany).
Design: Prospective, randomized study.
Setting: Infertility unit at Alexandria university hospital (Shatby IVF-ICSI LAB), and Madina IVF-ICSI Center.
Patient (s): Two hundred infertile couples undergoing IUI treatments.
Intervention(s): Patients were randomly assigned to undergo IUI treatment with either the Gynetics catheter (100 patients) or the Labotect catheter (100 patients).
Main Outcome Measure(s): Primary outcome measure was the clinical pregnancy rate.
Result (s): The use of the Gynetics catheter resulted in similar pregnancy (33% vs. 33%) and clinical pregnancy rates (20% vs. 19%) as compared with the Labotect catheter.
Conclusion (s): There was no significant difference in pregnancy rates with use of either the Gynetics catheter or the Labotect catheter.
Key Words: Catheter type in IUI & pregnancy rate.
References
1. Campana A, Sakkas D, Stalberg A, Bianchi PG, Comte I, Pache T, et al. Intrauterine insemination: evaluation of the results accor-ding to the women’s age, sperm quality, total sperm count per insemination and life table analysis. Hum Reprod 1996;11:732– 6.
2. Alborzi S, Motazedian S, Parsanezhad ME, Jannati S. Comparison of the effectiveness of single intrauterine insemination (IUI) versus double IUI per cycle in infertile patients. FertilSteril 2003;80:595–9.
3. Depypere H, Milingos S, Comhaire F. Intrauterine insemination in male subfe-rtility: a comparative study of sperm preparation using a commercial percoll kit and conventional sperm wash. Eur J Obst Gyn Repr Biol 1995;62:225–9.
4. Hughes EG. The effectiveness of ovulation induction and intrauterine insemination in the treatment of persistent infertility: a meta-analysis. Hum Reprod 1997;12:1865–72.
5. Noujua-Huttenen S, Tomas C, Bloigu R, Tuomivaara L, Martikainen H. Intrauterine insemination treatment in subfertility: an analysis of factors affecting outcome. Hum Reprod 1999;14:689 –703.
6. Omblet E, Vandeput H, Van de Putte G, Cox A, Janssen M, Jacobs P, et al. Intrauterine insemination after ovarian stimulation with clomiphene citrate: predictive potential of inseminating motile sperm count and sperm morphology. Hum Reprod 1997;12:1458– 63.
7. Meriano J, Weissman A, Greenblatt EM, Ward S, Casper RF. The choice of embryo transfer catheter affects implantation after IVF. FertilSteril 2000;74:678 – 82.
8. Van Weering HGI, Schats R, McDonell J, Vink JM, Vermeiden JPW, Hompes PGA. The impact of the embryo transfer catheter on the pregnancy rate in IVF. Hum Reprod 2002;17:666 –70.
9. Kovacs GT. What factors are important for successful embryo transfer after in vitro fertilization? Hum Reprod 1999;14:590 –2.
10. Goudas VT, Hammitt DG, Damario MA, Session DR, Singh AP, Dumesic DA. Blood on the embryo transfer catheter is associated with decreased rates of embryo implantation and clinical pregnancy with the use of in vitro fertilization-embryo transfer. Fertil Steril 1998;70:878 – 82.
11. Smith KL, Grow DR, Wiczyk HP, O’Shea DL, Arny M. Does catheter type affect preg-nancy rate in intrauterine insemination cycl-es? J Assist Reprod Genet 2002;19:49 –52.
12. Spiessens C, Demaeght O, Debrock S, Meeuwis L, Bakelants E, Meuleman C, et al. The type of catheter has no impact on the pregnancy rate after intrauterine insemination: a randomized study [abstract]. Hum Reprod 2003;18S1:75.
13. Lavie O, Margalioth EJ, Geva-Eldar T, Ben-Chetrit A. Ultrasonographic endometrial changes after intrauterine insemination: a comparison of two catheters. FertilSteril 1997;68:731– 4.
14. Karlström PO, Bergh T, Lundkvist O. A prospective randomized trial of artificial insemination versus intercourse in cycles stimulated with human menopausal gonadotropin or clomiphene citrate. FertilSteril 1993;59:554 –9.
15. Fanchin R, Olivennes F, Righini C, Hazout A, Schwab B, Frydman R. A new system for fallopian tube sperm perfusion leads to pregnancy rates twice as high as standard intrauterine insemination. FertilSteril 1995; 64:505–10.
16. 16 . Miller PB, Acres ML, Proctor JG, Higdon HL. Flexible versus rigid intrau-terine insemination catheters: a prospective, randomised, controlled study. FertilSteril 2005;83:1544-1546. 3rd and Boone WR.
17. NICE guideline. National Institute for Clinical Excellence; 2004. Fertility: assess-ent and treatment for people with fertility problems. Clinical guideline 11.February.
18. Schoolcraft WB, Surrey ES, Gardner DK. Embryo transfer: techniques and variables affecting success.
19. https://www.ncbi.nlm.nih.gov/pubmed/11704102FertilSteril. 2001 Nov;76(5):863-70.
20. Mamas L. Higher pregnancy rates with a simple method for fallopian tube sperm perfusion, using the cervical clamp double nut bivalve speculum in the treatment of unexplained infertility: a prospective randomised study. Hum Reprod1996; 11:2618-2622.