Title: A comparative study of HDL levels in ischaemic and haemorrhagic stroke in a tertiary care hospital in south Rajasthan
Authors: Dr Sourav Chattopadhyay, Dr Abhas Hissaria
DOI: https://dx.doi.org/10.18535/jmscr/v12i06.07
Abstract
Background: Stroke is an medical emergency which is 3rd most common cause of death in developed countries. The cumulative incidence of stroke ranged from 105 to 152/100,000 persons per year, and the crude prevalence of stroke ranged from 44.29 to 559/100,000 persons in different parts of the country during the past decade. These values were higher than those of high-income countries.
The WHO clinically defines stroke as “the rapid development of clinical signs and symptoms of focal neurological disturbance lasting more than 24 hours or leading to death with no apparent cause other than vascular origin.
Aim and Objectives:
- To compare the level of serum HDL level between two categories of stroke.
Objectives:
- To compare the levels of serum HDL and study of lipid profile between two categories of stroke.
Materials and Methods: Sample size is of 100 patients and case control study was done, with 50 patients having ischemic stroke and 50 having haemorrhagic stroke who presented in Geetanjali medical college, Udaipur. Detailed physical and neurological examination was done. Fasting blood sample, Random blood sugar was taken in plain tubes. Results were recorded.
Results: Study showed HDL was significantly decreased in ischemic stroke than hemorrhagic stroke and Total cholesterol, triglycerides, LDL, VLDL were more in ischemic stroke than hemorrhagic stroke.
Conclusion: This study shows that there is a significant decrease in HDL in ischemic stroke than Hemorrhagic stroke. As the Reverse Cholesterol Transport, Anti-inflammatory activity, Anti oxidative activity, Anti apoptotic activity, Endothelial repair, Anti thrombotic activity, Anti infectious activity of HDL are reduced due to decreased HDL leads to ischemic stroke than Hemorrhagic stroke.
References
- Kuriakose, D., & Xiao, Z. (2020). Pathophysiology and Treatment of Stroke: Present Status and Future Perspectives. International journal of molecular sciences, 21(20), 7609. https://doi.org/10.3390/ijms2120760
- Sanossian, N., Saver, J. L., Navab, M., & Ovbiagele, B. (2007). High-density lipoprotein cholesterol: an emerging target for stroke treatment. Stroke, 38(3), 1104–1109. https://doi.org/10.1161/01.STR.0000258347.19449.0
- Curb, J. D., Abbott, R. D., Rodriguez, B. L., Masaki, K. H., Chen, R., Popper, J. S., Petrovitch, H., Ross, G. W., Schatz, I. J., Belleau, G. C., & Yano, K. (2004). High density lipoprotein cholesterol and the risk of stroke in elderly men: the Honolulu heart program. American journal of epidemiology, 160(2), 150–157. https://doi.org/10.1093/aje/kwh177
- Yaghi, S., & Elkind, M. S. (2015). Lipids and Cerebrovascular Disease: Research and Practice. Stroke, 46(11), 3322–3328. https://doi.org/10.1161/STROKEAHA.115.011164