Background: Chronic kidney disease (CKD) is associated with premature atherosclerosis and increased incidence of cardiovascular morbidity and mortality. Several factors contribute to atherogenesis and cardiovascular disease in patients with CKD. Notable among the CKD-induced risk factors are lipid disorders, oxidative stress, inflammation, physical inactivity, anemia, hypertension, vascular calcification, endothelial dysfunction, and depressed nitric oxide availability.

Objective: To assess the pattern of lipid profile in chronic kidney disease patients along with comparision of lipid profile in chronic kidney disease patients with diabetes mellitus and without diabetes mellitus.

Methods: A total of 50 patients of chronic kidney disease (CKD)of age group 20-70 year and 50 age and sex matched healthy controls were included in this study. Blood specimens were collected from both groups and measurement of the lipid prfile, FBS, PPBS, S.creatinine and blood urea was done and compare results with the study group.

Results: Total cholesterol and LDL was significantly raised in patients of CKD compared to controls The triglycerides were elevated. However, the statistical analysis showed that it was not significant. There was statistically significant variation found in triglyceride, VLDL and HDL when compared with the comorbid conditions of hypertension.

Conclusion: There is significant amount of dyslipidemia is found in patients of CKD. so treatment of dyslipidemia will reduce mortality in CKD patients.

Keywords: CKD, lipid Profile, Hypertension, Diabetes mellitus.

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Dr Milav Bhavsar

Associate Professor, Department of Biochemistry, C.U Shah Medical College, Surendranagar, Gujarat, India, Pin: 363001

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