Background: The symptomatic improvement of Helicobacter pylori (H.pylori) infection can be achieved using standard triple therapy. Recently eradication rate of the regimen has declined and this study to find evidence how beneficially the symptoms can be reduced by the 14 day therapy.

Aim: To assess the symptomatic betterment from standard triple therapy.

Methods: Fifteen patients diagnosed with H.pylori infection were recruited for the study. They were administered with standard triple therapy for 14 day course. The regimen consists of Proton pump inhibitor (40 mg b.i.d), Amoxicillin (1000mg), Clarithromycin 500mg b.i.d).The symptoms were assessed using Gastrointestinal Symptom Rating Scale(GSRS) questionnaire. Patients completed GSRS questionnaire during the first week of treatment and after the completion of treatment.

Results: A total of 15 patients with RUT (Rapid Urease Test) positive for H.pylori were treated with standard triple therapy for 14 days. No patients were excluded due to an incomplete questionnaire. The overall symptom reduction after successful completion of therapy is 71.75%. In terms of five major symptom patterns like abdominal pain score, reflux score, indigestion score, diarrhoea and constipation score were also found to be reduced significantly.

Conclusion: Significant reduction in symptoms with H.pylori infection were seen in patients those complete the standard 14 day triple therpy. Patients were found to be symptomatically improved.

Keywords: Symptomatic improvement, Helicobacter pylori infection, Standard triple therapy, 14 day course, GSRS .

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Soumya R V

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