Background: Pleural effusion is an excessive accumulation of fluid in the space lies between the lung and chest wall i.e. pleural space¹. In normal condition, pleural space contains a film of fluid (near about of 10 ml of fluid on each side) between the parietal and visceral pleural. This pleural fluid acts as a lubricant and allows the visceral pleural to slide along the parietal during respiratory movements.

Aim of study: Role of various biochemical marker for the differential diagnosis of Exduative and Transudative pleural effusion.

Study Area: The present study will be conducted in PMCH, Udaipur.

Result: When comparing Exudative and Transudative pleural effusion the concentration in Exduative patients ADA level in pleural fluid (80.30 ± 35.03), serum (36.97 ± 14.50), ALP level in pleural fluid (129.41 ± 41.34), serum (190 ± 87.65), LDH level in pleural fluid (507.75 ±195.90), serum (739.03 ±259.59), The observation shows statistically significant differences (p) in both groups.

Conclusion: We observed that transudative pleural effusion appears in advance age groups but exudative pleural effusion seen in early age groups, the reasons behind that the etiological factor involve for transudative pleural effusion (Congestive cardiac failure, Chronic renal failure, Liver Cirrhosis) appear later in life i.e.>50 year.

Keywords: ADA, ALP, LDH, Pleural Effusion.

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Nita Sahi

Associate Professor Dept. of Biochemistry Pacific Medical College & Hospital Udaipur (Rajasthan), India