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Category: Volume 11 Issue 08 August 2023
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Title: Antioxidant in Oxidative Stress and Neurodegenerative Diseases

Authors: Tukur Zayyanu, Karnawat Monika

 DOI: https://dx.doi.org/10.18535/jmscr/v11i8.02

Abstract

Background: Natural substances have long been used for developing traditional medicines, and the production of innovative drugs is encouraged by the use of these natural ingredients. The key interaction between oxidative stress and inflammation in disease etiology is supported by mounting research. Reactive oxygen species (ROS) generated by inflammatory cells cause oxidative stress, which has been recognized as the key mediator of the relationship between inflammation and the spread for diseases.  Curcumin (DFM), demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC) are the three main components of the rhizomes of turmeric. That filters the superoxide radicals, nitric oxide, and hydrogen peroxide while inhibiting lipid peroxidation, a successful Nano medicine using a curcumin will result in treatment of age-related neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease.

Aims: The goal of this research is to present a new current Nano biotechnological approach to disease treatment and the use of encapsulated Nano cur cumin for treatment of age-related neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases.

Methods: In the study, amorphous calcium phosphate (ACP) nanoparticles were prepared by the co-precipitation method to optimize release profile of curcumin (Cur) and avoid burst releases, which were used to overcome the weakness of Cur, such as poor chemical stability and bioavailability. To find the best preparation condition, the influence of reaction concentration, temperature, time and pH on crystal phase of the samples was investigated by XRD and FTIR.

Results: The results showed that amorphous calcium phosphate (ACP) was obtained, when pH value and the concentration of PO4 3− were 8 and 0.024 mM, prepared at 30 °C for 10 min , ACP nanoparticles showed high loading capacity of Cur and favorable pH-responsive drug release properties. Thus the IC50 concentration (µg/ml) of curcumin: Calcium phosphate: Encapsulated NP: Inducer for Alzheimer’s disease: and Inducer for Parkinson’s disease where estimated respectively. 

Conclusion: Innovative Nano biotechnology techniques, such as Nano delivery-based strategies, are now being investigated to address current cur cumin bioavailability limitations.

Keywords: Oxidative Stress, Neurodegenerative Dseases, Encapsulated Nanoparticles. 

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Corresponding Author

Tukur Zayyanu

Career Point University, Alaniya, Kota, Rajasthan, India