Title: An Epidemiological Analysis of the 3rd Wave of SARS CoV-2 Genome Sequencing: A Peripheral Hospital-Based Study
Author: Pratiti Datta
DOI: https://dx.doi.org/10.18535/jmscr/v11i5.09
Abstract
SARS-CoV2 virus, a positive sense enveloped single standard RNA virus encoded with 29 proteins and host derived membrane. Structural proteins help virus to package its RNA and other proteins help in viral replication by enabling its entry into the host. Among structural proteins few important proteins are S which is the spike protein, resemble 33s like a crown, M, which is a hydrophobic membrane protein, E which is the envelope protein and N is the nucleocapsid protein works as RNA binding protein. Through the constant mutation virus changes its emergence profile. Single mutation is not always advantageous for virus, but combination of mutations causes increased transmissibility and increase receptor binding capacity thereby changes the surface structure. Whole genome sequencing is an important tool to assess the mutations and helps to understand the changing trends of the virus. Here we are reporting the genome sequencing of those patients who were already positive for RTPCR Tests. The aim, of the present study, is to identify the different lineages circulating in West Bengal as well as the epidemiological analysis of the set of patients to control the disease severity. During the (JULY 2021-AUG 2022). of COVID-19, there were mostly 2 strains delta and omicron. The epidemiological genome sequencing study helps to highlight on the coming and changing viral trends and helps in prevention of the newly arrived variants.
Keyword: SARS- COV2, Epidemiology, Mutation, Variant.
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