Title: Solid Pseudopapillary Neoplasm: A Case Report of a Rare Pancreatic Tumor

Authors: Dr Shikha Sharma, Dr Himani Thakur, Dr Sarita Asotra, Dr U K Chandel, Dr Kailash Mohan Bhandari

 DOI: https://dx.doi.org/10.18535/jmscr/v11i5.08

Abstract

Solid Pseudopapillary Neoplasm (SPN) of pancreas is a rare neoplasm with a reported incidence of 0.1-2.7% of all pancreatic tumors. SPN is mostly seen in young females. It has a low malignant potential and has an excellent prognosis. We report a case of 41 years old female who presented with an abdominal lump. A mass measuring9.4×6.2 cm was noted on CECT. The diagnosis of Solid Pseudopapillary Neoplasm of Pancreas was confirmed on histopathological examination. Being a rare tumor of pancreas, SPN is often missed on radiological examination. A solid/cystic mass on gross examination and microscopic presence of solid and papillary arrangement of cells is highly suggestive of SPN. Solid areas comprise of sheets and cords of round or ovoid, bland cells arranged on the perimeter of delicate fibrovascular septa. Malignant SPN, designated as a solid pseudopapillary carcinoma, is seen in about 15% of adult patients. Surgical resection of the tumor is the mainstay of therapy of SPN.Strict post-operative follow-up is necessary to keep a check on local and distant metastasis.

Keywords: Solid Pseudopapillary Neoplasm, SPN, Pancreas.

References

  1. Tez M, Ozalp N, Zulfikaroglu B, Koc M. A solid pseudopapillary tumor arising from mesocolon without ectopic pancreas. HPB Surg. 2010:206186.
  2. Shuja A, Alkimawi KA. Solid pseudopapillary tumor: a rare neoplasm of the pancreas. Gastroenterol Rep (Oxf). 2014;2(2):145-149.
  3. Yu PF, Hu ZH, Wang XB, Guo JM, Cheng XD, Zhang YL et al. Solid pseudopapillary tumor of the pancreas: a review of 553 cases in Chinese literature. World J Gastroenterol. 2010 Mar 14;16(10):1209-14.
  4. Lagausie DP, Sarnacki S, Orbach D, Petit P, Joubert C. Cystopapillary tumor of the pancreas (Frantz's tumor) in adolescents and young adults. The pseudopapillary tumor of the pancreas (or Frantz's tumor). Bulletin Du Cancer 2012; 99:112-116.
  5. Reddy S, Cameron JL, Scudiere J, Hruban RH, Fishman EK, Ahuja N, Pawlik TM et al. Surgical management of solid pseudopapillary neoplasms of the pancreas: A large single-institutional series, J. Am. Coll. Surg. 2009; 208: 950–959.
  6. Antoniou EA, Damaskos C, Garmpis N, Salakos C, Margonis GA, Kontzoglou K et al.Solid Pseudopapillary Tumor of the Pancreas (Review). Solid Pseudopapillary Tumor of the Pancreas: A Single-center Experience and Review of the Literature. In vivo;2017; 31: 501-510.
  7. Erguibi D, El Berni Y, Moufakkir A, Boufettal R, Rifki Jai Saad, Chehab F. Solid pseudopapillary neoplasm of the head of the pancreas: A case report. Annals of Medicine and Surgery 2021; 69: 102708.

Corresponding Author

Dr Sarita Asotra

Associate Professor, Department of Pathology, IGMC Shimla