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Category: Volume 11 Issue 02 February 2023
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Title: Renal cell carcinoma unsightly causing anemia and reactive thrombocytosis

Authors: Dr Roshni Mallepaka, Dr Gudupala Sri Charan, Dr Pamarthi Sai Krishna, Dr Saligommula Rajendraprasad

 DOI: https://dx.doi.org/10.18535/jmscr/v11i2.04

Abstract

A case of 45 years old female, Caucasian with anemia for more than anone year which was unnoticed for unknown period, not responding to any treatment like iron therapy and blood transfusions is reported here. Repeated Blood pictures showed severe anemia with severe reactive thrombocytosis. Fecal occult blood test done was found to be negative. Upper and lower gastrointestinal examination showed no evidence of bleed from any site. Abdominal ultrasound followed by CT scan abdomen and pelvis revealed right heterogeneously enhancing solid cystic mass. A US-guided biopsy was then taken; the histopathology revealed malignant tumor with pleomorphic/anaplastic morphology. On immunohistochemistry, atypical cells express PAX8 which is suggestive of either clear cell or papillary or chromophobe tumors. And so patient was advised for additional immunohistochemistry panel. So it mandates considering renal cell carcinoma in the workup part of the causes of iron deficiency anemia along with reactive thrombocytosis.

Keywords: iron deficiency anemia, reactive thrombocytosis, clear cell carcinoma.

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Corresponding Author

Dr Roshni Mallepaka

KNR University of Health sciences