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Category: Volume 10 Issue 12 December 2022
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Title: Oxidative Stress and Antioxidant Activity in Newborns and their Correlation with their Birth Weight

Authors: Ms. Mamta, Dr Aditi Ranawat, Dr Sandhya Mishra, Dr Oby Nagar

 DOI: https://dx.doi.org/10.18535/jmscr/v10i12.15

Abstract

Introduction

The weight of the infant at birth is a powerful predictor of infant growth and survival and depends on maternal health and nutrition throughout the pregnancy(1) Low birth weight has been defined by the World Health Organization (WHO) as weight at birth of less than 2500 g (5.5 lb)(2). In India prevalence of low birth weight neonate is 25–30 %(3). Maternal, fetal, placental, and external factors along with genetic growth potential throughout pregnancy are the major determinant of the normal growth of fetus. Impairments in one or more of these factors affect the fetal growth(4). There are various studies that reveal maternal as well as fetal risk factors for intrauterine growth retardation (IUGR). However, intrauterine growth retardation, which sometimes occurs without any risk factor, and etiopathogenesis could not be fully demonstrated. It can be understood by the thought that, in pathophysiology of intrauterine growth retardation, placental failure, which is contributed by oxidative stress, plays an important role(5).

Pregnancy is a stressful physiological condition and it has been associated with oxidative stress injury(6). Oxidative stress occurs when there is an imbalance in oxidant (free radical) and antioxidant. Free radicals react with membrane lipids and starts a chain of reactions result in formation of an intermediate lipid peroxidation product; Malondialdehyde (MDA). This is being measured widely to show the evidence of free radical injury in biological sample.(7) This study was designed to correlate oxidative stress (MDA) & Total Antioxidant activity (AOA) and birth weight of new-borns.

Keywords: Oxidative stress, Malondialdehyde (MDA), Total Antioxidant Activity (AOA), Birth weight, Newborn

References

  1. Muthayya S. Maternal nutrition and low birth weight—what is more important? IndianJ Med Res. 2009;130:600–8.
  2. World Health Organization. International statistical classification of diseases and related health problems, tenth revision. Geneva: World Health Organization; 1992.
  3. Park K. Park’s textbook of preventive and social medicine. 21st Jabalpur: M.S. Banarsidas Bhanot; 2011. p. 494.
  4. Bernstein PS, Divon MY. Etiologies of fetal growth restriction.Clin Obstet Gynecol 1997; 40: 723- 29.
  5. Sankaran S, Kyle PM. Aetiology and pathogenesis of IUGR. Best Pract Res Clin Obstet Gynaecol 2009; 23: 765- 77
  6. Kinga Toboła-Wróbel , 1 Marek Pietryga , 1,2 Piotr Dydowicz,2 Marta Napierała , 3 Jacek Brązert,1 and Ewa Florek 3.  Association of Oxidative Stress on Pregnancy. Oxidative Medicine and Cellular Longevity Volume 2020, Article ID 6398520, 12 pages
  7. Dolapo P.Daniel A A.,Adeniram S. A, Abolape A.I,Patric T.A,Cord blood oxidative stress Markers correlate with birth and placenta weight.Journal of Asian scientific Research,2013,3(4):365-372.
  8. Buge JA Aust SD Microsomal lipid peroxidation Method  enzymol 1978; 52:302-10.
  9. Karacay O, Sepici-Dincel A, Karcaaltincaba D, Sahin D, Yalvaç S, Akyol M, et al. A quantitative evaluation of total antioxidant status and oxidative stress markers in preeclampsia and gestational diabetic patients in 24–36 weeks of gestation. Diabetes Res Clin Pract. 2010;89(3):231–8.
  10. Kais AI-Gubory. Catherine Garrel.The role of cellular reactive oxygen species, oxidative stress and antioxidants in pregnancy outecomes. The international journal of biochemistry and cell biology 2010 42(10) 1634-1650.
  11. Preedy, Victor R Effects of Antioxidants and Oxidative Stress on Pregnancy and Infant Growth: Korean Perspectives .Handbook of growth and growth monitoring in health and disease. PP-1585-1598
  12. Agarwal A, Mellado A, Premkumar BJ, Shaman A, Gupta S. The effects of oxidative stress on female reproduction. A review. Reproductive Biology and Endocrinology. 2012;10:49–80. [PMC free article][PubMed] [Google Scholar]
  13. Pizzino.Na Irrera, M. cucinoto,G. pallio, F. Mannio, V. Arcoraci, F. Squardrito, D. Altavilla,A.Bitto.Oxidative stress:harm and benefits for human health. Oxid.Med Cell Longev.2017:2017:8416763.
  14. Dolapo Pius OPARINDE, Daniel Adebode Adekanle, Adeniran Samuel Atibacord Blood  Oxidative  Stress  Markers  Correlate  with  birth and Placenta Weight Journal of Asian Scientific Research, 2013,3(4):365-372.
  15. Kim YJ, Hong YC, Lee KH, et al. Oxidative stress in pregnant women and birth weight reduction. Reprod Toxicol 2005; 19 487-92.
  16. Ahmed H. Al-Anee*, Salam Shihab**, Hazim H. Edan**, Jasim Aljanabee** *Evaluation of serum malondialdehyde in relation to other clinical considerations in premature neonates Dept. of Pediatrics, College of Medicine, Tikrit University. * *Dept. of Biochemistry, College of Medicine, Tikrit University
  17. Hiromichi Shoji, Naho Ikeda, Mariko Hosozawa, Natsuki Ohkawa, Nobuaki Matsunaga, Hiroki Suganuma, Ken Hisata, Kyoko Tanaka and Toshiaki Shimiz uOxidative stress early in infancy and neurodevelopmental outcome in very low-birthweight infants
  18. Jyothi M. P. D’souza1 · Sindhu Harish1 · Vinitha Ramanath Pai1· Chitra Shriyan2Increased Oxidatively Modified Forms of Albumin in Association with Decreased Total Antioxidant Activity in Different Types of Hypertensive Disorders of Pregnancy Ind J Clin Biochem (Apr-June 2017) 32(2):200–206
  19. Matern Fetal Neonatal Med 2012 Aug; 25(8): 1338-41  doi 10.3109/14767058.2011.633672. Epub 2011 Nov 21.
  20. Matern Fetal Neonatal Med 2012 Aug; 25(8):1338-41  doi 10.3109/14767058.2011.633672. Epub 2011 Nov 21.

Corresponding Author

Dr Aditi Ranawat