Title: A Study of Cardiac Troponin T in Patients with end Stage Renal Disease
Authors: Dr K. Rajarammohanarao, Dr K. Sudheer, Dr B. Ashokbabu, Dr Y. Rakesh
DOI: https://dx.doi.org/10.18535/jmscr/v10i12.06
Abstract
Introduction
- End stage renal disease /Chronic Kidney Disease is a clinical syndrome caused by different underlying renal pathology.
- The cardio vascular disease is the leading cause of death in End stage renal disease/Chronic Kidney Disease (Chronic Kidney Disease stages 3-5). These patients develop clinically silent myocardial injury.
- Hence, a clinically silent Cardiac pathology underlies these cardiac troponin T elevations. This elevated cardiac troponin T is a specific marker of myocardial cell injury in patients of End stage renal disease/Chronic
- Kidney Disease because of high organ specificity of cardiac troponin T.
- The Increase in plasma concentration of the cardiac troponin T protein, clearly indicates myocardial cell injury.
- Cardiovascular complications like myocardial injury in End stage renal disease/Chronic Kidney Disease (Chronic Kidney Disease stages 3-5) occurs very early in the progression of Chronic Kidney Disease.
- Hence early detection of myocardial injury by measuring cardiac troponin T will help to detect and treat the cardiac complications in End stage renal disease/Chronic Kidney Disease (Chronic Kidney Disease stages 3-5).
- Cardiac Troponin T, a Tropomyosin-binding protein of the regulatory complex located on the contractile apparatus of cardiac myocytes.
- It is elevated in non ischemic type of chronic myocardial injury and can be used as a marker of cardiac myocytes injury.
Aims & Objectives
- To determine whether serum cardiac Troponin T is elevated in patients with End stage renal disease/Chronic Kidney Disease (Chronic Kidney Disease stages 3-5).
- Early detection of myocardial cell injury by estimating serum cardiac Troponin T levels in patients with End stage renal disease/Chronic Kidney Disease (Chronic Kidney Disease stages 3-5).
References
- Sharma R. Gaze DC. Pellerin D. Mehta RL. Gregson H. Streather CP. Cardiac structural and functional abnormalities in end stage ten& disease patients with elevated cardiac troponin T. Heart 2006:92:804-809.
- Dierkes J. Domrose U. Westphal S. et al. Cardiac troponin T predicts morality in patients with end-gage renal disease. Circulation 2000;10119641969.
- Morbidity and mortality of renal dialysis: on N1H consensus conference statement. Ann Intern Med. 1994:121:62-70.
- Deegan, PB, Lafferty ME, Blumsohn A, Henderson IS, McGregor E. Prognostic value of Troponin T in haemodialysis patients is independent of comorbidity. Kidney Int 2001:60: 2399-405.
- Lowbeer C. Stenvinkel P, Pecotis-Filho R. Heimburger O. Lindholm B Gustafsson SA. Seeberger A.. Elevated cardiac troponin T in predialysis patients is associated with inflammation and predicts mortality. J Intern Med 2003:253: 153-160.