Title: A Rare Case of steroid responsive ITP Post Dengue Fever in an Adult Female

Authors: Mounica Kalidindi, P. Goutham Reddy, Kondal Rao.D

 DOI: https://dx.doi.org/10.18535/jmscr/v10i11.17

Abstract

ITP (immune or idiopathic thrombocytopenic purpura) is an acquired disorder in which there is immune-mediated destruction of platelets and possibly inhibition of platelet release from the megakaryocyte. ITP is characterized by mucocutaneous bleeding, low or very low platelet count, with an otherwise normal peripheral blood smear. Dengue cases generally present with thrombocytopenia and bleeding manifestations but thrombocytopenia generally recovers within 8 to 10 days of dengue, but in our case the thrombocytopenia is persistent and presented after months of recovery from dengue

Keywords: Dengue, Persistent Thrombocytopenia, ITP, Steroids

References

  1. Harrison's principles of internal medicine 21st edition
  2. Sharma M, Chandan GS, Arayamparambil PV, Gopalakrishna UK. Case of Near Fatal Massive Intracerebral Bleed Secondary to Cerebral Venous Thrombosis in a Patient with Dengue and Refractory Thrombocytopenia. Indian J Crit Care Med. 2020 Feb;24(2):138-140. doi: 10.5005/jp-journals-10071-23351. PMID: 32205948; PMCID: PMC7075060. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075060
  3. Roy S. Thrombopoietin Receptor Agonists: Can These Be the Future Answer to the Deadly Thrombocytopenia in Dengue Fever? Cureus. 2019 Apr 1;11(4):e4361. doi: 10.7759/cureus.4361. PMID: 31192066; PMCID: PMC6550512. https://pubmed.ncbi.nlm.nih.gov/31192066
  4. Robbins and Cotran pathologic basis of disease
  5. Bennett J, Brown C, Rouse M, et al. (July 09, 2020) Immune Thrombocytopenia Purpura Secondary to COVID-19. Cureus 12(7): e9083. doi:10.7759/cureus.9083 https://www.cureus.com/articles/33674-immune-thrombocytopenia-purpura-secondary-to-covid-19

Corresponding Author

Dr P. Goutham Reddy

Nimra Hospital, Jupudi, Ibrahimpatnam, pin code-521456, Andhra Pradesh, INDIA