Title: Serological and virological profile of viral hepatitis (Hepatitis B and C) in and around Aligarh region
Authors: Parvez Anwar Khan, Kanchan Singh, Sarita Mallik, Sanjay Sharma, Haris Manzoor Khan
DOI: https://dx.doi.org/10.18535/jmscr/v10i9.15
Abstract
Introduction: Viral hepatitis especially hepatitis B and hepatitis C infection is one of the main public health problem affecting million of people. This study was performed in the Department of Microbiology, JNMCH, AMU, Aligarh, to determine the prevalence, serological and virological profile of patients with HBV and/or HCV infection.
Methods: A laboratory based study was carried out on patients with suspected viral hepatitis to find out the clinical profile, spectrum of viral hepatitis infections and the correlation between serology and viral load. Patient blood samples were recruited from the OPDs and Wards from the patients presenting with signs and symptoms of hepatitis. Serum samples were tested for HBsAg, anti HCV antibodies and HBeAg, anti HBc IgM by ELISA test. Viral Load of HBV and HCV was done by fully automated Quantitative Real-time PCR.
Results: A total of 3512 samples of HBV and HCV were investigated, out of which 316 (8.99%) patients were found to be positive for vital hepatitis positive. These 316 cases of confirmed viral hepatitis were observed positive during January to May 2022. Occurance of HBsAg positive patients were 194(61.3%), A-HCV were 114(36.0%), HBeAg were 4(1.26%) and A-HBc IgM 2(0.63%) and, 8(2.53%) were positive for both HBsAg and A-HCV. Out of 316 positive patients, 150 (47.4%) were male and 166 (52.5%) were female. The majority of male and female patients are found in the age group of 21-40.
Conclusions: Our study provided the information about prevalence of hepatitis B and C, patient’s serology and virology profile with viral hepatitis infection and risk transmission. The incidence of HBV and HCV infection were endemic at an intermediate level in the geographical area of Aligarh, Uttar Pradesh. Sufficient measures and intervention are need to be taken by government and public health sector for risk prevention and health education among population to reduce viral infection between adults.
Keywords: HBV hepatitis B virus; HCV hepatitis C virus; HBsAg hepatitis B surface antigen; risk factors.
References
- Malhotra, Parveen, et al. "Prevalence, hepatitis B and hepatitis C in tertiary care center of Northern India." Adv Res Gastroentero Hepatol4 (2020): 80-82.
- Hamida, M. E., Raja, S. M., Seyoum, Y., Elkhidir, I. M., & Tekle, F. (2020). Serological and virological profile of patients with chronic hepatitis B infection in Eritrea. J. Clin. Virol, 4, 96-101.
- Ahmad, I., Sami, H., & Mustafa, Z. (2020). Investigation of Hepatitis A virus outbreak in Aligarh and its peripheral areas, Uttar Pradesh, India. J Microbiol Exp, 8(4), 156-161.
- Lesi, O. A., Audu, R. A., Okwuraiwe, A. P., Adeleye, O. O., Ige, F. A., & Iwuorah, J. C. (2019). Serological and virological markers of nigerian patients with hepatitis B infection. Nigerian Journal of Clinical Practice, 22(4), 534-538.
- Javadi, Ali Abbas, M. Avizhgan, and Masoud Hafizi. "Prevalence of HBV and HCV infections and associated risk factors in addict prisoners." (2006): 33-36.
- Reddy, G. A., Dakshinamurthy, K. V., Neelaprasad, P., Gangadhar, T., & Lakshmi, V. (2005). Prevalence of HBV and HCV dual infection in patients on haemodialysis. Indian journal of medical microbiology, 23(1), 41-43.
- Chevaliez, S., & Pawlotsky, J. M. (2006). Hepatitis C virus serologic and virologic tests and clinical diagnosis of HCV-related liver disease. International journal of medical sciences, 3(2), 35.
- Mittal, G., Gupta, P., Gupta, R., Ahuja, V., Mittal, M., & Dhar, M. (2013). Seroprevalence and risk factors of hepatitis B and hepatitis C virus infections in uttarakhand, India. Journal of clinical and experimental hepatology, 3(4), 296-300.
- Baha, W., Foullous, A., Dersi, N., They-they, T. P., Nourichafi, N., Oukkache, B. & Bennani, A. (2013). Prevalence and risk factors of hepatitis B and C virus infections among the general population and blood donors in Morocco. BMC public health, 13(1), 1-8.
- Bennani, A., Baha, W., Dersi, N., Ennaji, M. M., Lazaar, F., El Malki, A., & Hassar, M. (2011, December). Hepatitis B & C epidemiology in Morocco. In BMC Proceedings(Vol. 5, No. 1, pp. 1-1). BioMed Central.