Details
Category: Volume 10 Issue 09 September 2022
Hits: 781

Title: An Unusual Presentation of Merkel Cell Carcinoma of the Gluteal Region with Brain Metastases: A Rare Case Report

Authors: Dr Rahul Mahawar, Dr T. Dhaneshor Sharma, Dr Ak. Sunita Devi

 DOI: https://dx.doi.org/10.18535/jmscr/v10i9.01

Abstract

Merkel cell carcinoma (MCC) is a small cell rare and aggressive neuroendocrine carcinoma arising in the skin. It usually arises in sun-exposed regions. It is associated with advanced age, ultraviolet (UV) radiation and polyomavirus infection. This paper reports a case of a 39-year-old male patient who underwent wide local excision of the left gluteal lesion. The biopsy report of the excised specimen showed features consistent with Merkel cell carcinoma. The patient had received adjuvant chemotherapy and palliative radiotherapy to the brain for brain metastasis. In view of poor general condition, the patient was kept on supportive care and he expired eight months after the of start of treatment.

Keywords: brain metastasis, gluteal, merkel cell carcinoma, neuroendocrine.

References

  1. Bachmann J, Kleeff J, Bergmann F, et al. Pancreatic metastasis of Merkel cell carcinoma and concomitant insulinoma: case report and literature review. World J SurgOncol 2005; 3(58):1-7.
  2. Haag ML, Glass LF, Fenske NA. Merkel cell carcinoma: diagnosis and treatment. Dermatol Surg 1995; 21(8):669-83.
  3. Stang A, Becker JC, Nghiem P, et al. The association between geographic location and incidence of Merkel cell carcinoma in comparison to melanoma: An international assessment. Eur J Cancer 2018; 94:47-60.
  4. Coggshall K, Tello TL, North JP, et al. Merkel cell carcinoma: An update and review: Pathogenesis, diagnosis, and staging. J Am Acad Dermatol 2018; 78:433-42.
  5. Bichakjian CK, Lowe L, Lao CD, et al. Merkel cell carcinoma: critical review with guidelines for multidisciplinary management. Cancer 2007; 110:1-12.
  6. Turkkan G, Agdogan O, Saynak M, et al. Recurrent Merkel cell carcinoma of the gluteal region: A case report. Dermatol Ther 2019; 32: e12749.
  7. Harms KL, et al. Analysis of prognostic factors from 9387 Merkel cell carcinoma cases forms the basis for the new 8th edition AJCC staging system. Ann Surg Oncol 2016; 23(11):3564–71.
  8. Marcoval J, Ferreres JR, Penín RM, et al. Merkel cell carcinoma: differences between sun-exposed and non-sun exposed variants--a clinical analysis of 36 cases. Dermatology 2014; 229:205-9.
  9. He W, Zhang D, Jiang J, et al. Merkel cell carcinoma in the left groin: a case report and review of the literature. Oncol Lett 2015; 9:1197-200.
  10. Nghiem P, Jaimes N. Merkel cell carcinoma. In: Wolff K, Katz S, Goldsmith L, Gilchrest B, Leffell D, Paller A, editors. Fitzpatrick’s dermatology in general medicine. 7th ed. USA: McGraw-Hill; 2008.
  11. Allen PJ, Bowne WB, Jaques DP, et al. Merkel cell carcinoma: Prognosis and treatment of patients from a single institution. J Clin Oncol 2005; 23:2300‑9.
  12. Feletti A, Marton E, Rossi S, et al. Pituitary metastasis of Merkel cell carcinoma. J Neurooncol 2010; 97:295-9.
  13. Medina-Franco H, Urist MM, Fiveash J, et al. Multimodality treatment of merkel cell carcinoma: case series and literature review of 1024 cases. Ann Surg Oncol 2001; 8:204–8.
  14. Eng TY, Boersma MG, Fuller CD, et al. Treatment of merkel cell carcinoma. Am J Clin Oncol 2004; 27(5):510-5.
  15. Pectasides D, Pectasides M, Economopoulos T. Merkel cell cancer of skin. Ann Oncol 2006; 17(10):1489-95.
  16. Honeybul S. Cerebral metastases from Merkel cell carcinoma: long-term survival. J Surg Case Rep 2016; 10:165.

Corresponding Author

Dr Rahul Mahawar

PGT, Dept. of Radiation Oncology, RIMS, Imphal, Manipur