Title: To Study the Effects of Comparison of Insulin plus OHA versus Combination of OHA Alone in Type 2 Diabetes Mellitus
Authors: Dr Md Zamin Ahsan, Dr Taskeen Ahmad Reza, Dr Pramod Kumar Agrawal, Dr Rakesh Raushan
DOI: https://dx.doi.org/10.18535/jmscr/v10i1.21
Abstract
Background
In type 2 diabetes with secondary OHA failure, therapy with combination of multiple oral hypoglycaemic agents or combination of oral hypoglycaemic agent with insulin is known to improve glycemia in patients with type 2 diabetes mellitus, the best combination to achieve target fasting plasma glucose concentration of less than 130mg/dl or glycosylated hemoglobin (HbA1C) below 7% is not very clear.
Aims and Objectives
- To study the effect of combination oral hypoglycaemic agent with and without insulin on glycemic control, lipid profile and
- To compare the beneficial effects in the above two study group
Methods
This present study was a cross sectional, hospital based, non-randomized, and comparative study conducted at the hospital attached to Katihar Medical College. A total of 100 Type 2 DM patients fulfilled the inclusion criteria, divided into two groups: those who received combination of oral hypoglycemic agent with the insulin (comb OHA+INS) and those who received combination oral hypoglycemic agent (comb OHA) alone. These groups were evaluated for baseline demographic, diabetic characteristics, glycemic control, lipid profile and BMI. These two groups were compared with respect to glycemic control, lipid profile and BMI.
References
- Turner RC, Coll CA, Frighi V, Holman RR. For UK prospective diabetes Study group: Glycemic control with diet,s ulfonylurea, Metformin or Insulin in patient with type 2 Diabetes Mellitus; progressive requirement for multiple therapies (UKPDS 49) JAMA 1999;281: 2005-2012
- Franz MJ, Warshan H, Daly AE. Evolution of diabetes. Medical nutrition Therapy. Postgrad Med J 2003;79:30-35.
- Krall LP, Bradley RF. Secondary failure in the treatment of diabetes Mellitus with Tolbutamide and phenformin. Diabetes 1962;11:88-91
- Delawtes DE, Moss SM.Tyroles’s secondary failure of response to Tolbutamide treatment.