Title: Levels of AMH in Main Phenotypes of PCOS and its role in predicting severity of PCOS
Authors: Dr Meenakshi Rana, Dr Kamini Randhawa
DOI: https://dx.doi.org/10.18535/jmscr/v9i10.06
Abstract
Background: The ultimate pathogenesis of polycystic ovary syndrome is not well known but the failure of follicular maturation leading to accumulation of preantral and small antral follicles and anovulation, both of these significantly contribute to production and increased levels of AMH.
Objectives: To characterize the difference in circulating anti mullerian hormone level between main phenotypic groups and evaluate the role of AMH in predicting the severity of PCOS.
Design: Prospective observational study
Setting: Department of Obstetrics and Gynecology, KNHSH IGMC Shimla.
Subjects: 200 women of age group 15-35 yearwith complaints of menstrual irregularities or symptoms of hyperendrogenism fulfilling the inclusion and exclusion criteria were included.
Methods: Serum levels of FSH, LH, Prolactin, TSH, FBS and AMH were measured on 2nd day of natural cycle. For qualitative variables frequency/percentage was calculated and for quantitative variables mean/ standard deviation was calculated and compared.
Results: The mean serum AMH levels were 8.3 +_ 3.63 ng/mL in Group 1, 8.02+_4.2 ng/mL in Group 2, 7.89 +_4.4 ng/mL in Group 3, and 6.1+_2.4 ng/mL in Group 4. The highest levels of AMH were found in Group 1. All other parameters were comparable among all four group.
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