Title: Sero Surveillance Study to Monitor the Trends of SARS COV2 Infection in the Pediatric Population of the Goa State
Authors: Dr Varsha Munj, Dr Shanti P. D’Almeida, Dr Utkarsh Bethodkar, Dr Tripti Gaonkar
DOI: https://dx.doi.org/10.18535/jmscr/v9i9.25
Abstract
Background: As there are concerns raised of anticipated 3rd wave of Covid- 19 to hit the state of Goa around August-October 2021 wherein pediatric population is likely to be affected, conducting pediatric population based sero-surveillance will help to estimate and monitor the trends of infection that will guide the strategy for making further decisions.
Materials and Methods: The sero -epidemiological investigation for COVID 19 infection is a pediatric population based cross-sectional study (5-11years and 12-17 years). The sample size was calculated for each of the age group and strata (District).480 samples were analysed by serological test to determine SARS COV2 antibodies (quantitative spike proteins).
Results: 480 children were considered for the study as per the survey design. 319 were tested positive for SARS COV2 antibody .The overall seroprevalence of SARS- COV2 antibody in children (5-17 years) of Goa state is 66.40% with North district (68.33%) and South district (64.58%). 54% were females and 46% were males. 57% of children were in the age group of 5-11 years whereas 43% were in the age group of 12-17 years. 13% of children presented with mild to moderate symptoms while 87% of children were asymptomatic. The seroprevalence was similar in rural and urban areas of Goa. Betki(North District) had positivity of only 29.17% and Canacona and Ponda (South District) had positivity of 37.5%.
Conclusion: SARS COV2 seropositivity in children 5-17 years is higher in Goa state. Vaccine priority can be given age group of 11-17 years. There is heterogenecity in distribution of cases indicating possibility of further waves.
Keywords: SARS-COV Antibody, EFLA, spike-protein (IgM) Antibody.
References
- World Health Organization (WHO). Seroepidemiological investigation protocol for coronavirus 2019 (COVID-19) infection.
- World Health Organization. Report of the WHO-China joint mission on coronavirus disease 2019 (COVID-19); 16-24 February 2020.Geneva: WHO; 2020.
- Van Seventer JM, Hochberg NS. Principles of infectious diseases: transmission, diagnosis, prevention, and control. Int Encycl Public Health 2017; 6:22–39.
- Doyle T, Kendrick K, Troelstrup T, Gumke M, Edwards J, Chapman S, et al. COVID-19 in primary and secondary school settings during the first semester of school reopening — Florida, August–December 2020. Morb Mortal Wkly Rep 2021;70(12):437–41.
- The Unity Studies: WHO Sero-epidemiological Investigations Protocols: Available from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/technical-guidance/early-investigations
- https://www.hindustantimes.com/india-news/kids-adults-have-similar-antibodies-sero-survey-101623953000262.html
- http://timesofindia.indiatimes.com/articleshow/82348019.
- https://www.business-standard.com/article/current-affairs/more-than-50-kids-in-mumbai-have-covid-19-antibodies-sero-survey-121062801229_1.html
- Puneet Misra et al.Serological prevalence of SARS-CoV-2 antibody among children and young age (between age 2-17 years) group in India: Medrxiv open.2021 ;pgs 1-10.
- Abate BB, Kassie AM, Kassaw MW, Aragie TG, Masresha SA. Sex difference in coronavirus disease (COVID-19): a systematic review and meta-analysis. BMJ open. 2020 Oct 1;10(10):1-10