Title: Cytomorphological Study Emphasizing Early Diagnosis of Mesothelioma in a Tertiary Care Centre in Southern Rajasthan
Author: Dr Rini Bishnoi
DOI: https://dx.doi.org/10.18535/jmscr/v9i8.15
Abstract
Background: Malignant Mesothelioma (MM) is a rare and aggressive tumour of the pleura and peritoneum associated with short survival time and needs timely diagnosis which varies with different histological subtypes.
Aim: To evaluate the incidence and clinicomorphological features of malignant mesothelioma with emphasis on early diagnosis by cytology.
Materials and Methods: A total of 78 cases of malignant mesotheliomas of different sites encountered over a 2-year period were retrospectively analysed with regard to their cytological findings and subsequent histopathology subtyping and follow up with patient survival.
Results: Environmental asbestos exposure was found in 75.00% of patients. The pleura was the most common site of involvement (76 cases)with one case of pericardial and peritoneal mesothelioma. Epithelioid mesothelioma was the most common histological type (62 cases, 79.4%) followed by sarcomatoid, desmoplastic and biphasic (4 cases each, 6.4%)and deciduoid (2 cases, 3.2%). All the cases diagnosed on FNA/Effusion cytology were confirmed by histopathology and subtyping was done. Mean patient survival time was 9 months.
Conclusion: Malignant mesothelioma related to asbestos exposure is seen rampantly in active mining areas of Southern Rajasthan and is associated with poor survival rates, which emphasizes the need for early diagnosis and histological subtyping for better patient outcomes.
Keywords: Histological type;cytology; mesothelioma.
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