Title: Generalized Eruptive Histiocytosis: Mimicking many dermatosis

Authors: Dr Sourabh Sharma, Dr GR Tegta

 DOI: https://dx.doi.org/10.18535/jmscr/v9i6.49

Abstract

Generalized eruptive histiocytosis (GEH) is a rare, benign, self-healing and generalized cutaneous histiocytosis that mainly affects adults and presents with multiple symmetric papules on face, trunk, and proximal extremities. We report a case with atypical presentation of GEH, a rare type of non-langerhans cell histiocytosis. GEH is a very close clinico-pathplogical mimicker of not only leprosy and diffuse cutaneous leishmaniasis but a lot of other dermatosis. So a detailed clinical workup, meticulous histopathological examination and most important immmunohistochemical assessment is recommended for early diagnosis. Although spontaneous involution is the rule but a close follow-up is necessary to evaluate for underlying diseases or evolution into more severe types of histiocytoses.

Keywords: GEH, Mimicker, Disease.

References

  1. Winkelmann RK, Muller SA. Generalized eruptive histiocytoma: a benign popular histiocyticreticulosis. Arch Dermatol 1963; 88: 586–596.
  2. Matsushima Y, Ohnishi K, Ishikawa O. Generalized eruptive histiocytoma of childhood associated with rheumatic fever. Eur J Dermatol 1999; 9: 548–550
  3. Tamiya H, Tsuruta D, Takeda E, Moriwaki K, Kobayashi H, Ishii M. Generalized eruptive histiocytoma with rapid progression and resolution following exanthema subitum. Clin Exp Dermatol 2005; 30: 300–301.
  4. Statham BN, Fairris GM, Cotterill JA. Atypical eruptive histiocytosis – a marker of underlying malignancy? Br J Dermatol 1984; 110: 103–105
  5. Saijo S, Hara M, Kuramoto Y, Tagami H. Generalized eruptive histiocytoma: a report of a variant case showing the presence of dermal indeterminate cells. J Cutan Pathol 1991; 18: 134–136.
  6. Marzano AV, Facchetti M, Caputo R. Generalized eruptive histiocytosis (histiocytoma). Eur J Dermatol 2002; 12: 205–206.
  7. Caputo R, Ermacora E, Gelmetti C, Berti E, Gianni E, Nigro A. Generalized eruptive histiocytoma in children. J Am Acad Dermatol 1987; 17: 449–454.
  8. Ashworth J, Archard L, Woodrow D, Cream JJ. Multiple eruptive histiocytoma cutis in an atopic. Clin Exp Dermatol 1990; 15: 454–456.
  9. Repiso T, Roca-Miralles M, Kanitakis J, Castells-Rodellas A. Generalized eruptive histiocytoma evolving into xanthoma disseminatum in a 4-year-old boy. Br J Dermatol 1995; 132: 978–982.
  10. Zelger BW, Sidoroff A, Orchard G, Cerio R. Non-Langerhans cell histiocytoses. A new unifying concept. Am J Dermatopathol 1996; 18: 490–504.
  11. Braun-Falco O, Korting HC, Zienicke H, Klovekorn W. Eruptive histiocytoma and xanthoma disseminatum as manifestations of the same disease? Hautarzt 1988; 39: 652–657.
  12. Sidoroff A, Zelger B, Steiner H, Smith N. Indeterminate cell histiocytosis: a clinicopathological entity with features of both X- and non-X histiocytosis. Br J Dermatol 1996; 134: 525–532.
  13. Ferrando J, Campo-Voegeli A, Soler-Carrillo J, Munoz E, Sole M, Palou J. Systemic xanthohistiocytoma: a variant of xanthoma disseminatum? Br J Dermatol 1998; 138: 155–160.

Corresponding Author

Dr GR Tegta

Head of Department, Department of Dermatology, Venereology and Leprosy, IGMC Shimla