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Category: Volume 09 Issue 06 June 2021
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Title: A Rare Case Report on Lipodystrophy of Perinodal Adipose Tissue Mimicking Metatstatic Signet Ring Cell Adenocarcinoma in a Cachexic Patient

Authors: Dr Abhilash Singh, Dr Anchana Gulati

 DOI: https://dx.doi.org/10.18535/jmscr/v9i6.32

Abstract

Cachexia is a complex syndrome and a comorbid condition commonly associated with a variety of chronic diseases like cancer, congestive heart failure, chronic obstructive pulmonary disease, chronic kidney disease and AIDS cancer. It results from metabolic dysregulation and is characterized by profound loss of adipose tissue and skeletal muscles. Approximately 20% of deaths in cancer patients are due to cachexia. Adipose tissue after undergoing cachectic dystrophy may mimics signet ring cell morphology histologically. Such lipodystrophied adipocytes mimicking signet ring cells are a diagnostic pitfall. We present a case of 54 years old male presenting with complains of pain upper abdomen for 1.5 years along with dysphagia and vomiting for last 4-5 months, diagnosed as moderately differentiated adenocarcinoma, biopsy pyloric stricture with metastatic tumor deposits in omental lymph node and lipodystrophy of adipocytes in the perinodal tissue.

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Corresponding Author

Dr Anchana Gulati, Associate Professor