Title: ACUTE AND SUB ACUTE TOXICITY STUDY ON SIDDHA DRUG CUṆṬIYĀTI CŪRAṆAM

Authors: Dr Sheela E, Dr Manoharan A, Dr Komalavalli T, Santhanakumar M

 DOI: https://dx.doi.org/10.18535/jmscr/v9i6.20

Abstract

The bronchial Asthma is the most common disease in India, because our country have more industrial area . It is the most common in allergic disease of human beings leading to more complication. The present study was investigated the acute sub-acute toxicity study of cuṇṭiyāti cūraṇam for the management of CUVĀCA KĀCAM (Bronchial Asthma), following OECD guidelines 423 and 407 method 28 days repeated oral toxicity studies were done on both sex of Wister albino rats.In acute and sub-acute toxicity studies no toxic effects were observed upto the dose level of 2000 mg/kg body weight and carried in five different groups in CC was administrated and dose ranging from 5, 50, 300, 1000, 2000 mg/kg for rat respectively. No mortality effect was observed up to 2000 mg/kg of body weight in acute and sub-acute toxicity study.

Keywords: cuṇṭiyāti cūraṇam, acute toxicity, sub-acute toxicity.

References

  1. Anoop A, Jagadeesan A, Subramaniam S, Toxicological study on LingacchenduramI. a Siddha drug, IJPS, 2002; 64(1):53.
  2. Bürger C, Fischer DR, Cordenunzzi DA, Batschauer de Borba AP, Filho VC, Soaresdos Santos AR. Acute and subacute toxicity of the hydroalcoholic extract from Wedeliapaludosa (Acmelabrasilinsis) (Asteraceae) in mice. J. Pharm. Sci. (www.cspsCanada.org) 2005; 8(2):370-373. 
  3. R. Pearson, R.J. McCrimmon/ Davidson’s Principles and Practice of Medicine/22nd Edition/2014/22nd edition.
  4. Gergen PJ/Weiss KB/Epidemiology of Asthma/Asthma and rhinitis/Blackwell scientific publications/1995/Chapter3.
  5. http://en.wikipedia.org/wiki/asthma.
  6. https://www.who.int/news-room/fact-sheets/detail/asthma.
  7. Jain N, Sharma P, Sharma N, Joshi SC. Haemato-biochemical profile following sub-acute toxicity of malathion in male albino rats. Pharmacologyonline. 2009; 2:500-506.
  8. OECD Guideline 407 for testing of chemicals. Repeated dose 28-Day Oral Toxicity Study in Rodents. 2008; pp 2-8. 
  9. OECD Guideline for testing of Chemicals (2001) Guideline 423: Acute Oral Toxicity-Acute Toxic Class Method.

Corresponding Author

Dr Manoharan A

Professor & HOD, Dept. of Pothu Maruthuvam, Government Siddha Medical College & Hospital, Palayamkottai-627002, Tirunelveli, Tamil Nadu