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Category: Volume 09 Issue 06 June 2021
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Title: Study of Lipid Parameters in Ischemic Stroke Patients

Authors: Arvind Kumar, Prem Singh, Gaurav Gupta, Brijesh Kumar, Mahendra Singh, S.K. Gautam, Tanu Midha

 DOI: https://dx.doi.org/10.18535/jmscr/v9i6.04

Abstract

Background: Stroke is one of the most frequent causes of death and disability worldwide with a significant clinical and socioeconomic impact. The objectives were to know whether there is a role for dyslipidemia in the occurrence of ischemic strokeand if there is any difference in the various lipid parameters of the case and control groups.

Aims and Objective: To determine the role of lipid parameters on the occurrence of ischemic stroke and its comparison with age and sex-matched controls.

Material and Methods: A case-control study was done and a total of 48 patients with acute ischemic stroke were chosen. An equal 48 controls were included in this study for the comparison of outcome. A serum sample after 8 hours of overnight fasting was taken on the next day of admission for both groups of patients. Total serum cholesterol, triglycerides, LDL-cholesterol, and HDL-cholesterol were determined, using the enzymatic colorimetric method.

Results: In 48 ischaemic stroke patients, raised serum total cholesterol was seen in 11, triglyceride in 15 and LDL-cholesterol in 16 patients. On the other hand, raised serum total cholesterol observed in 10, triglyceride in 12, LDL-cholesterol in 12 age and sex matched 48 control subjects. Serum HDL-cholesterol was below the normal reference in 09 cases and 04 controls subjects. On comparison, no statistical significance was found on comparing abnormal values of both groups for total cholesterol, triglycerides, LDL-C and HDL-C. Also after comparing mean values for different lipid parameters no significant association observed in our study.

Conclusion: We found that lipid profile values are not associated with an increased risk of ischaemic stroke.

Keywords: Diabetes, Dyslipidemia, Infarct, Ischemia.

References

  1. Khan NI, Naz L, Mushtaq S, Rukh L, Ali S, Hussain Z. Ischaemic stroke: prevalence of modifiable risk factors in male and female patients in Pakistan. Pak J Pharm Sci 2009; 22:62-7.
  2. World Health Organization. The world health report: shaping the future. Geneva: WHO; 2003
  3. Kouna NP, Millogo A, Siemefe KF, Assengone ZY. Epidemiological and progressive aspects of stroke at the Hospital Center of Libreville. African J Neurol Scien. 2007;26:12-7.
  4. Hollander M, Koudstaal PJ, ML Bots, Grobbee D, Hofman A, Breteler M. Incidence, risk and case fatality of ever stroke in the elder population. The Rotterdam study. J neurolneurosurg Psychiatry. 2003 Mar; 74 (3):317-21.
  5. Kim AS, Johnston SC. Temporal and geographic trends in the global stroke epidemic. Stroke. (2013) 44: S123–5. DOI:10.1161/STROKEAHA.111.000067.
  6. Feigin VL, Norrving B, Mensah GA. Global burden of stroke. Circ Res. (2017) 120:439–48. DOI: 10.1161/CIRCRESAHA.116.308413.
  7. Khan J, Attique-ur-Rehman, Ali SA, Jielani A. Frequency of hypertension in stroke patients presenting at Ayub Teaching Hospital. J Ayub Med Coll Abbottabad 2006; 18:59-61.
  8. García-Moll X. Inflammation, Atherosclerosis, Classic Cardiovascular Risk Factors, Biostatistics, Clinical Significance. Where Are We? Rev Esp Cardiol. 2007;60(12):1220-2.
  9. Banerjee TK, Mukherjee CS, Sarkhel A. Stroke in the urban population of Calcutta-and epidemiological study. Neuroepidemiology 2001;20:201-7.
  10. Austin MA, King MC, Vranizan KM, Krauss RM. Atherogenic lipoprotein phenotype. A proposed genetic marker for coronary heart disease risk. Circulation. 1990;82:495-506.
  11. Togha M, Gheini MR, Ahmadi B, Razeghi PKS. Lipid profile in cerebrovascular accidents Iran J Neurol. 2011;10(1-2):1-4.
  12. Goldstein LB. Statins for stroke prevention. Curr Atheroscler Rep2007; 9:305-11.
  13. Pandian JD, Sudhan P. Stroke epidemiology and stroke care services in India. Journal of Stroke. 2013;15:128-34.
  14. Zhang X, Patel A, Horibe H, Wu Z, Barzi F, Rodgers A, MacMahon S, Woodward M; Asia Pacific Cohort Studies Collaboration. Cholesterol, coronary heart disease and stroke in the Asia Pacific region. Int J Epidemiol. 2003 Aug;32 (4):563-72. DOI:10.1093/ije/dyg106. PMID: 12913030.
  15. Lindenstrøm E, Boysen G, Nyboe J. Influence of total cholesterol, high density lipoprotein cholesterol, and triglycerides on risk of cerebrovascular disease: the Copenhagen City Heart Study. BMJ. 1994 Jul 2;309(6946):11-5. doi: 10.1136/bmj.309.6946.11. Erratum in: BMJ 1994 Dec 17;309(6969):1619. PMID: 8044059; PMCID: PMC2542648.
  1. Qizilbash N, Duffy SW, Warlow C, Mann J. Lipids are risk factors for ischaemic stroke: overview and review. Cerebrovasc Dis 1992; 2:127-36.
  2. Park JH, Kwon HM. Association between metabolic syndrome and previous ischaemic lesions in patients with intracranial atherosclerotic stroke. Clin Neurol Neurosurg 2008; 110: 215-21.
  3. Russman AN, Schultz LR, Zaman IF, Rehman MF, Silver B, Mitsias P, et al.A significant temporal and quantitative relationship exists between high-density lipoprotein levels and acute ischaemic stroke presentation.J Neuro Sci 2009;279:53-6.
  4. Butterworth RJ, Marshall WJ, Bath PMW. Changes in serum lipid measurements following acute ischaemic stroke. Cerebrovasc Dis 1997; 7:10-3.

Corresponding Author

Gaurav Gupta