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Category: Volume 09 Issue 04 April 2021
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Title: Mean platelet volume: Significance in patients with IBD: Ulcerative Colitis

Authors: Anuvind T, I Shubha, Caroline Selvi K, K Premkumar, R Murali, A Chezhian

 DOI: https://dx.doi.org/10.18535/jmscr/v9i4.13

Abstract

Background: Mean platelet volume (MPV) and inflammatory markers are affected in chronic inflammatory diseases. In this study we aimed to investigate the correlation of MPV with disease activity in patients with IBD: Ulcerative Colitis based on the UCEIS score.  The UCEIS consists of the following three descriptors and was calculated as a simple sum: vascular pattern (scored 0–2); bleeding (scored 0–3); and erosions and ulcers (scored 0–3). Therefore, the range of UCEIS scores is 0–8.

Materials and Methods: A total of 120 subjects were enrolled. The study group consisted of 40 patients with Ulcerative Colitis and the control group included 80 healthy subjects. Groups were compared regarding MPV and disease activity score - UCEIS.

Results: Groups were similar in terms of age, sex (p=0.23, 0.43, respectively). MPV levels were higher in patients with UC patients 9.71 compared to the controls 11.27  (p= 0.02). A significant correlation was found between MPV and UCEIS Score in patients.

Conclusion: MPV was found to be decreased in patients with IBD compared to the controls and there is a negative correlation with disease activity indices.

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Corresponding Author

Anuvind T

Institute of Medical Gastroenterology, Madras Medical College, The Tamil Nadu Dr. M.G.R Medical University, Chennai, Tamil Nadu, India