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Category: Volume 09 Issue 04 April 2021
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Title: p53 Expression in Surface Epithelial Ovarian Tumors and its Correlation with Histological Type and Grade of the Tumor

Authors: Dr Abhilash Singh, Dr Neelam Sharma, Dr Lalita Negi, Dr Rajeev Sood

 DOI: https://dx.doi.org/10.18535/jmscr/v9i4.07

Abstract

Introduction

Ovarian cancer is the sixth most common female cancer worldwide1 and accounts for a significant number of deaths from malignancies of the female genital tract2. It is considered to be the most lethal gynaecological malignancy10. Its incidence rates are higher in developed than developing countries. The age standardized incidence rates of ovarian cancer for 2020 in world and India is 6.6 and 6.7 respectively. In most of the population-based cancer registries in India, ovarian cancer is the third leading site of cancer among women, trailing behind cervix and breast cancer. Indian Cancer Registry data project ovary as an important site of cancer in women, comprising up to 8.7% of cancers in different parts of the country.9

About 80% ovarian tumours are benign and occur in younger age group comprising of 20-45 years however, malignant tumours are more common in 40-65years. Important etiological risk factors are increasing age, positive family history, increase age of reproduction, high socio-economic classes, and nulliparity11.

References

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Corresponding Author

Dr Neelam Sharma

Professor, Department of Pathology, IGMC, Shimla