Title: Acute paraplegia as a manifestation of COVID-19

Authors: Sithara Subair, MBBS, Anuradha H, P Paranthaman, MD

 DOI: https://dx.doi.org/10.18535/jmscr/v9i3.39

Abstract

Background: One of the many complications of COVID-19 infection is the risk of arterial and venous thromboembolism owing to cytokine storm and hypercoagulability. Here we report one such patient who presented with paraplegia and limb ischemia due to an aortic thrombus.

Case Information: 56-year old obese diabetic lady presented with sudden onset complete paraplegia with absent lower limb pulsations. CT angiogram showed aortic thrombus extending from level of renal artery origin till bilateral common iliac artery bifurcation, while CT chest showed CO-RADS 4, moderate COVID pneumonia, with a negative RTPCR on nasopharyngeal swab. While less common, several cases of aortic thrombosis as a result of COVID-19 infection have been described, attributed to the “thromboinflammatory” state seen in severe cases.

Conclusion: This report is to highlight the various differential diagnoses of acute aortic occlusion, with key reference to COVID -19 and associated hypercoagulability.

Keywords: SARS-CoV-2, arterial thrombosis, COVID-19 complication, acute paraplegia,aortic thrombosis.

References

  1. Creager MA, Kaufman JA, Conte MS. Clinical practice. Acute limb ischemia. N Engl J Med. 2012 Jun 7;366(23):2198-206. doi: 10.1056/NEJMcp1006054. PMID: 22670905.
  2. Crawford JD, Perrone KH, Wong VW, Mitchell EL, Azarbal AF, Liem TK, Landry GJ, Moneta GL. A modern series of acute aortic occlusion. J Vasc Surg. 2014 Apr;59(4):1044-50. doi: 10.1016/j.jvs.2013.10.080. Epub 2014 Jan 3. PMID: 24393282.
  3. Cervera R, Piette JC, Font J, Khamashta MA, Shoenfeld Y, Camps MT et al; Euro-Phospholipid Project Group. Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients. Arthritis Rheum. 2002 Apr;46(4):1019-27. doi: 10.1002/art.10187. PMID: 11953980.
  4. Galli M, Luciani D, Bertolini G, Barbui T. Lupus anticoagulants are stronger risk factors for thrombosis than anticardiolipin antibodies in the antiphospholipid syndrome: a systematic review of the literature. Blood. 2003 Mar 1;101(5):1827-32. doi: 10.1182/blood-2002-02-0441. Epub 2002 Oct 3. PMID: 12393574.
  5. Martí-Carvajal AJ, Solà I, Lathyris D, Dayer M. Homocysteine-lowering interventions for preventing cardiovascular events. Cochrane Database Syst Rev. 2017 Aug 17;8(8):CD006612. doi: 10.1002/14651858. CD006612.pub5. PMID: 28816346; PMCID: PMC6483699.
  6. Teuwen LA, Geldhof V, Pasut A, Carmeliet P. COVID-19: the vasculature unleashed. Nat Rev Immunol. 2020 Jul;20(7):389-391. doi: 10.1038/s41577-020-0343-0. Erratum in: Nat Rev Immunol. 2020 Jun 4. PMID: 32439870; PMCID: PMC7240244.
  7. Lowenstein CJ, Solomon SD. Severe COVID-19 Is a Microvascular Disease. Circulation. 2020 Oct 27;142(17):1609-1611. doi 10.1161/CIRCULATIONAHA.120.050354. Epub 2020 Sep 2. PMID: 32877231; PMCID: PMC7580651.
  8. Libby P, Lüscher T. COVID-19 is, in the end, an endothelial disease. Eur Heart J. 2020 Sep 1;41(32):3038-3044. doi: 10.1093/eurheartj/ ehaa623. PMID: 32882706; PMCID: PMC7470753.
  9. Panigada M, Bottino N, Tagliabue P, Grasselli G, Novembrino C, Chantarangkul V, et al. Hypercoagulability of COVID-19 patients in intensive care unit: A report of thromboelastography findings and other parameters of hemostasis. J Thromb Haemost. 2020 Jul;18(7):1738-1742. doi: 10.1111/jth.14850. Epub 2020 Jun 24. PMID: 32302438.
  10. Irizarry L, Wray A, Guishard K. Acute Paraplegia as a Presentation of Aortic Saddle Embolism. Case Rep Emerg Med. 2016; 2016:1250153. doi: 10.1155/2016/ 1250153. Epub 2016 Oct 16. PMID: 27822396; PMCID: PMC5086356.

Corresponding Author

Sithara Subair, MBBS

Junior Resident, Department of Internal Medicine, Govt Kilpauk Medical College and Hospital, Chennai. India