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Category: Volume 09 Issue 03 March 2021
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Title: Comparative efficacy of Amoxycillin Vs Cefixime in the treatment of Childhood enteric fever in a tertiary level Hospital in Bangladesh

Authors: Md. Miraz Ali, Md Nazmul Hassan, Md Rafiqul Islam, Md Rukunuzzaman

 DOI: https://dx.doi.org/10.18535/jmscr/v9i3.32

Abstract

The study aims to assess the clinical efficacy of amoxycillin in comparison to cefixime in the treatment of childhood typhoid fever and to reduce morbidity and mortality from typhoid fever. This was an age and sex matched interventional study on inpatient and outpatients children of below 14 years of pediatrics department of Rangpur Medical College Hospital, Bangladesh from September 2013 to February 2014.A total 60 child diagnosed with typhoid fever was evaluated in this study. Male-female ratio was 1.31:1.0, most of them in between 1 to 5 years of age. Majority of patients (58.3%) were normal or mildly wasted. In most cases fever was continued (63.3%) in nature followed by intermittent (36.6%) in nature. Cure was achieved in amoxicillin and in cefixime group 73.3% and 83.3% respectively. Differences between two groups were not statistically significant. There was no significant difference between two groups in respect of cure rate and defervescence period. Also there was no serious adverse effect were found between two groups. Amoxycillin is effective and safe drug in the treatment of childhood enteric fever. Its efficacy is comparable with that of cefixime.

Keywords: Enteric fever, Typhoid fever, Oral drugs for enteric fever.

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Corresponding Author

Dr Md. Nazmul Hassan

Department of Paediatric Gastroenterology & Nutrition,

Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh