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Category: Volume 09 Issue 02 February 2021
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Title: Correlation of platelet indices with glycaemic control and vascular complications in diabetic patients in a tertiary Hospital based study

Authors: Dr Aparajita Sharma, Dr Sunil Arora, Dr Shivangi Singh

 DOI: https://dx.doi.org/10.18535/jmscr/v9i2.30

Abstract

Background: Diabetes Mellitus (DM) is a group of metabolic disorders, characterised by chronic hyperglycaemia, metabolic abnormalities which lead to multiple complications1.Mean Platelet Volume (MPV) and Platelet Distribution Width (PDW) are related to platelet size, enzymatic activity and prothrombotic potential, these parameters are easily obtained by automated haematology analysers at a relatively low cost. This study was accordingly taken with the aim to correlate the platelet indices with glycosylated haemoglobin (HbA1c) levels and also to determine the correlation of the platelet indices with diabetic complications.

Methods: The present study was a comparative prospective study, conducted from march 2020 to September 2020 at the Pathology department, SGT Medical college, Gurugram during the period of seven months on 119 diabetic patients.

Results: The majority of patients were in the age group of 51-70 years. Most of the patients showed bad glycaemic control, out of 119 patients, 97 patients showed HbA1C to be more than 6.5%. Fasting blood glucose in group with HbA1C < 6.5 % and in group with HbA1C > 6.5 % were 140.78±3.12 mg/dl and 178.34±11.95 mg/dl respectively, which was highly significant between the two groups with p-value 0.001. All the platelet indices (platelet count, PDW and MPV) were found to be raised in patients with HbA1C > 6.5 %. Value of mean FBG, mean platelet count, MPV between the two groups shows statistically significant difference in their p value. Out of 119 patients, 90 patients were without any complications. Fasting blood glucose is raised in patients with diabetic complications and is statistically significant. Platelet count in diabetics with complication was found to be 2.79±0.46 lakh/cumm in comparison to the platelet count in diabetics without complications which was 2.69±0.65 lakh/cumm and is not statistically significant.

Conclusion: Increased mean fasting blood glucose, mean platelet count and MPV show significant association with glycaemic control and mean fasting blood glucose and glycaemic control show significant association with vascular complication. During routine haematological analysis higher platelet indices can easily be recognised and antiplatelet treatment may prevent disease progression.

Keywords: Diabetes Mellitus, Platelet indices, MPV, PDW.

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Corresponding Author

Dr Aparajita Sharma

PG 3rd Year, Pathology Department, SGT University