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Category: Volume 09 Issue 02 February 2021
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Title: The effect of endocrine disruptors on endometrial cells: A Systematic Review

Authors: Muna Omer Alamoudi, Nada Ibrahim Alaqah, Ebtisam Ahmad Alrshedy, Latifa Ghazi Alshaya

 DOI: https://dx.doi.org/10.18535/jmscr/v9i2.29

Abstract

Endocrine disruptor plays a role as natural hormones in the body like estrogens or androgens, or thyroid hormones. It may act as the interaction of natural hormones with their receptor, or bind to a receptor and prevent the endogenous hormone from binding with their receptors. Endometrial tissue finds in uterus has gland, cells, and connective tissue. This tissue prepares the uterus for ovulation. The objectives of this review were to identify the effect of endocrine disruptors on endometrial cells. Electronic searches of literature were performed. From 38 titles, Full-text versions of the 15 identified titles were obtained and evaluated independently by two reviewers 8 of the full-text articles were excluded based on the established criteria. This process identified 7 articles for inclusion and data extraction. According the existing literatures, this study concluded that endocrine disruptors can affect on endometrial cells by regulate the expression of decidualization genes. But it can also cause endometrial dysfunction, disrupt vascular development and play important roles in tumorigenesis. The existing literatures reporting on this are small in volume and can be considered of generally low quality.

Keyword: Endocrine, Disruptors, Endometrial Cells, Endometrial Decidualization, Bisphenol A.

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Corresponding Author

Muna Omer Alamoudi

Biology Department, Faculty of Science, University of Hail PO Box 2240, Hai'l 81451, Saudi Arabia