Title: Transfusion related acute lung injury and necrotizing enterocolitis in a neonate

Authors: Dr Subhasree Beura, Dr Meghmala Sadhukhan, Dr Baikuntha Narayan Mishra

 DOI: https://dx.doi.org/10.18535/jmscr/v9i2.10

Abstract

Transfusion related acute lung injury (TRALI) and transfusion associated NEC (TANEC) are potentially life-threatening complications of blood component transfusion. These are relatively under diagnosed entity in neonates with scant literature. We report a case of TRALI and TANEC in a relatively stable preterm newborn developing acute respiratory distress and abdominal distension within few hours of blood product transfusion.

Keywords: preterm, transfusion, necrotizing enterocolitis, respiratory distress.

References

  1. Kopko PM, Marshall CS, MacKenzie MR, Holland PV, Popovsky MA. Transfusion-related acute lung injury: Report of a clinical look-back investigation.  JAMA .2002;287:1968–71. [PubMed] [Google Scholar]
  2. Gupta S, Som T, Iyer L, Agarwal R. Transfusion related acute lung injury in a neonate. Indian J Pediatr. 2012 Oct;79(10):1363-5. doi: 10.1007/s12098-011-0668-6. Epub 2011 Dec 29. PMID: 22205378.
  3. Nishimura M, Hashimoto S, Takanashi M, Okazaki H, Satake M, Nakajima K. Role of anti-human leucocyte antigen class II alloantibody and monocytes in development of transfusion-related acute lung injury. Transfus Med. 2007;17:129–34. [PubMed] [Google Scholar]
  4. Blau J, Calo JM, Dozor D, Sutton M, Alpan G, La Gamma EF. Transfusion-related acute gut injury: necrotizing enterocolitis in very low birth weight neonates after packed red blood cell transfusion. J Pediatr. 2011;158(3):403–409. [PubMed] [Google Scholar]
  5. Mohamed A, Shah PS. Transfusion associated necrotizing enterocolitis: a meta-analysis of observational data. 2012;129(3):529–540. [PubMed] [Google Scholar]
  6. Maria A, Agarwal S, Sharma A. Acute respiratory distress syndrome in a neonate due to possible transfusion-related acute lung injury. Asian J Transfus Sci. 2017; 11(2):203-205. doi:10.4103/ajts.AJTS_120_16
  7. Jasani B, Rao S, Patole S. Withholding Feeds and Transfusion-Associated Necrotizing Enterocolitis in Preterm Infants: A Systematic Review. Adv Nutr. 2017;8(5):764-769. Published 2017 Sep 15. doi:10.3945/an.117.015818

Corresponding Author

Dr Subhasree Beura

Neonatal Fellow, Dept. of Pediatric, AMRI Hospital, BBSR