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Category: Volume 08 Issue 09 September 2020
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Title: Vitamins D Toxicity in Paediatric Age Group: A Retrospective Cross Sectional Study

Authors: Pooja Mishra, Bijayendra Nath Chaturvedi, Prabhawati Banerjee

 DOI: https://dx.doi.org/10.18535/jmscr/v8i9.29

Abstract

Background: Vitamin D is an essential element for body health with its supplements generally administered to prevent vitamin D deficiency. Since these supplements are available in domestic settings, vitamin D toxicity may happen in children.

Methods: All children younger than 12 years who presented to the pediatric emergency department of our Hospital with history of ingestion of more than 1500 IU/day of vitamin D supplements were enrolled. Patients’ demographic data, on-presentation signs and symptoms, laboratory findings, treatments given, and outcome were evaluated.

Result: Fifteen patients presented during the study period. Their mean age was 46.53 ± 10.14 months and 12 (80%) were girls. All of them had unintentionally ingested vitamin D. Mean ingested dose was 406700.7 ± 227400.1 IU. In eight patients (53.3%), 25 hydroxy vitamin D level was more than 100 ng/mL. One patient experienced hypercalcemia while all of them were asymptomatic and discharged without complications. There was no significant difference between patients with and without high levels of 25 OH vitamin D regarding lab tests, toxicity course, and outcome.

Conclusions: It seems that acute vitamin D toxicity is a benign condition in our pediatric population which may be due to high prevalence of vitamin D deficiency in India.

Keywords: Vitamin D deficiency, Vitamin D toxicity, Paediatric age group.

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Corresponding Author

Dr Pooja Mishra

Junior Resident, Department of Paediatrics, Mata Gujri Memorial Medical College & LSK Hospital, Kishanganj, Bihar, India