Title: Challenges in the postoperative period following resection of a massive retroperitoneal sarcoma: A case report

Authors: Anila V B, Karthika Asokan, Rajasree O, Nimmy George, Shalina Chandran

 DOI: https://dx.doi.org/10.18535/jmscr/v8i8.29

Abstract

Intraoperative and postoperative period after major oncologic surgeries pose several challenges to the anaesthesiologist and the intensivist. This is a report of a huge retroperitoneal sarcoma for which wide excision and colo-colic anastomosis was done. The patient required massive blood transfusion during intraoperative period and had a stormy postoperative course in the intensive care unit (ICU) due to urosepsis, fecal peritonitis and fungal sepsis. Each of these complications was tackled promptly and appropriately. Fungal sepsis deserves a special mention in critically ill cancer patients due to their prolonged hospital stay and immunocompromised status.

Keywords: Retroperitoneal sarcoma; massive blood transfusion; fecal peritonitis, fungal sepsis; caspofungin; case report.

References

  1. Nunez TC, Young PP, Holcomb JB, Cotton BA: Creation, implementation, and maturation of a massive transfusion protocol for the exsanguinating trauma patient. J Trauma. 2010;68:1498-505.doi: 10.1097/TA.0b013e3181d3cc25
  2. Patil V, Shetmahajan M: massive transfusion and massive transfusion protocol, Indian J Anaesth. 2014[cited 2020 Aug 11];58:590-5. doi: 10.4103/0019-5049.144662
  3. Scotland KB, Lo J, Grgic T, Lange D. Ureteral stent-associated infection and sepsis: pathogenesis and prevention: a review. Biofouling. 2019;35(1):117-127. doi:10.1080/08927014.2018.1562549
  4. Farkas JD. The complete blood count to diagnose septic shock. J Thorac Dis. 2020;12(Suppl 1):S16-S21. doi:10.21037/jtd.2019.12.63
  5. Vijayan AL, Vanimaya, Ravindran S, et al. Procalcitonin: a promising diagnostic marker for sepsis and antibiotic therapy. J Intensive Care. 2017;5:51. Published 2017 Aug 3. doi:10.1186/s40560-017-0246-8
  6. Morgan J, Meltzer M et al: excess mortality, hospital stay, and cost due to candidemia: a case-control study using data from population-based candidemia surveillance, Infect Control Hosp Epidemiol 2005 jun: 540-547. doi: 10.1086/502581.
  7. Blot SI, Vandewoude KH, Hoste EA, et al. Effects of nosocomial candidemia on outcomes of critically ill patients. Am J Med 2002;113(6):480–5.
  8. Ostrosky-Zeichner L, Sable C, Sobel J, et al. Multicenter retrospective development and validation of a clinical prediction rule for nosocomial invasive candidiasis in the intensive care setting. Eur J Clin Microbiol Infect Dis 2007;26(4):271–6.
  9. Dodds Ashley ES, Lewis R, Lewis JS, Martin C, Andes D: pharmacology of systemic antifungal agents, Clin Infect Dis 2006; 43:S28-39.doi: 10.1086/504492.
  10. Pappas PG, Kauffman CA, Andes D, et al. Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis 2009;48(5):503–35.

Corresponding Author

Nimmy George

Postgraduate student, Department of Anaesthesiology, Regional Cancer Centre, Trivandrum, India