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Category: Volume 08 Issue 08 August 2020
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Title: Prevalence of Hepatitis C Virus Genotypes in Jammu: A Hospital Based Observational Study

Authors: Dr Perika, Dr Priyanka Sharma, Dr Shashi Sudhan Sharma, Dr Vijant Singh Chandail, Dr Konika Razdan

 DOI: https://dx.doi.org/10.18535/jmscr/v8i8.22

Abstract

Background and Objectives: Hepatitis C Virus (HCV) is an emerging infection in India and one of the major global health issues with an overall prevalence of 1%, among which 71 million people are living with chronic HCV infection. Every year 1.7 million of hepatic burden is added with an estimated 399,000 deaths. In India, North eastern tribal populations, and areas of Punjab are the major hotspots of HCV infection.  HCV has been divided into 8 genotypes, each showing wide variation in their distribution. The present study was designed to estimate the prevalence of various HCV genotypes in Jammu region of J&K and study the correlation between detected genotypes and clinical presentation.

Materials and Methods: Blood samples of patients attending the Department of Medicine, Government Medical College, Jammu referred to VRDL section, Department Of Microbiology, GMC Jammu for serological testing by anti-HCV ELISA wherein the positive samples were subjected to genotyping.

Results: This study showed that, out of 50 HCV positive patients, 37 (74%) were positive for genotype 3, 8 (16 %) for genotype 1, 1 (2%) for genotype 4 and in 4 (8 %) genotype couldn’t be detected.

Conclusion:  Jammu region of J&K has very few reports on the prevalence of HCV infection and hence knowledge of the predominant HCV genotypes is important for better management of chronic HCV infection and also helps clinicians in guiding appropriate antiviral therapy.

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Corresponding Author

Dr Shashi S Sharma

Professor, PI and Nodal Officer, Dept. of Microbiology, GMC Jammu, India