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Category: Volume 08 Issue 08 August 2020
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Title: A Comparative Study on the Effectiveness of Topical Phenytoin Dressing with Conventional Vaseline gauze/Chlorhexidine Tulle Grasse Dressing in Donor area of Split Skin Graft patients in a tertiary care teaching hospital

Authors: Dr Sunil Kumar Mallanaik, Dr Siddharth Nayak K

 DOI: https://dx.doi.org/10.18535/jmscr/v8i8.11

Abstract

Introduction: Phenytoin is an antiepileptic drug used in the treatment of generalized tonic clonic seizures and complex partial seizures The stimulatory effect of phenytoin on connective tissue suggested an exciting possibility for its use in wound healing. This study aims to compare the effectiveness of topical phenytoin powder with Vaseline/Chlorhexidine tullegrasse dressing in hastening healing of donor area in post SSG patients.

Materials and Methods: A prospective case control study involving patients fulfilling inclusion criteria for a period of one year was done. Medical case file information was collected and used for comparision between two groups of patients, one group whose donor area of graft was dressed with Vaseline/ Chlorhexidine Tulle grasse dressing and other phenytoin soaked gauze. Sample size was of 20 cases and controls each. They were reviewed serially at Days 5,10, 3weeks and 3months following surgery for graft uptake inspection and also daily for a week following surgery for their pain scale.

Results: Majority (70%) of the patients in both groups were found to be in the age of 30-60 years. Almost half of the cases and controls had PIRA as indication 45% of cases were hypoalbuminic and 35% were anemic,35% of controls were diabetic and 30% were obese. Addictions such as smoking and alcoholism were similar in both groups. Most cases (75%) and controls (95%) showed complete healing and had completed follow up. All cases showed improved pain control and post operative comfort compared to controls.

Conclusion: We found that phenytoin dressing was a cheaper and easily available method when compared to other modalities. Though phenytoin dressing is inferior compared to newer modalities, it was superior in comparision to Vaseline/Chlorhexidine dressing with higher patient compliance greater pain relief faster healing rates and cost effectiveness. Further comparative studies with a wider study group with more coexistent comorbid conditions are required to further merit.

Keywords: Phenytoin, Seizures, Wound Healing, Chlorhexidine.

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Corresponding Author

Dr Sunil Kumar Mallanaik

Mysore MMCRI