Title: High serum ferritin as a sensitive biomarker for diagnosis, follow up, prognosis and management of rheumatoid arthritis, brucellosis, malignancies, DM type 2 and vitamin b12 deficiency

Authors: Abdel Jawad Salim Salem, Eman Yousef Hassan Ayady, Yaser Kamel Hassan Amran

 DOI: https://dx.doi.org/10.18535/jmscr/v8i6.104

Abstract

The serum of ferritin used as biomarker of different diseases. This paper aimed at studying the possibility of using ferritin on diagnosing diseases. To accomplish that, random sample of subjects included in this research. The results showed that the serum of ferritin can be used as a biomarker of some diseases, while in some cases it did not reflect the disease level. The study recommended that the use of ferritin serum level can be used as first indicator for diseases but still deep diagnosis required to complete the disease level of patients.

Keywords: Serum ferritin, biomarkers, chronic diseases.

References

  1. Chen, S. Huang and D. Kerr, "Biomakers in clinical medicine," in Integration of Biomarkers into Epidemiology Study Designs, 2011, pp. 303-322.
  2. Koppe, D. Doneda and M. e. a. Siebert, "The prognostic value of the serum ferritin in a southern Brazilian cohort of patients with Gaucher disease," Genetics and Molecular Biology , vol. 39, no. 1, pp. 30-34, 2016.
  3. Chlou and J. Connor, "Emerging and dynamic biomedical uses of ferritin," Pharmaceuticals , vol. 11, p. 124, 2018.
  4. Rameh and A. Kossaify, "Role of biomarkers in the diagnosis, risk assessment, and management of pulmonary hypertension," Libertas Academia: Biomarkers Insights, pp. 85-89, 2016.
  5. Kell and B. Pretoritus, "Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage products from damage cells," Metallomics, vol. 6, p. 748, 2014.
  6. Goeb, P. Fardellone, J. Sibilia and F. Ponchel, "Biomarkers in Rheumatoid Arthritis," Mediators of Inflammation , vol. 2014, 2014.
  7. Knovich, J. Storey, L. Coffman and S. Torti, "Ferritin for the clinician," Blood Rev. , vol. 23, no. 3, pp. 95-104, 2009.
  8. Atzeni, R. Talotta, I. Masala and e. al., "Biomarkers in Rheumatoid Arthritis," IMAJ, vol. 19, pp. 512-516, 2017.
  9. Gandhi, A. Chaudhari, S. Prantinidhi and A. Sontakke, "Study of serum ferritin and HbA1c in type 2 diabetes mellitus," International Journal of Clinical Biochemistry and Research, vol. 5, no. 4, pp. 594-598, 2018.
  10. Kashinakunti, K. Hiremath, M. Rangappa and G. Kallaganada, "Serum ferritin level in type 2 diabetes mellitus: A case control study," International Journal of Clinical Biochemistry and Research, vol. 3, no. 1, pp. 62-66, 2016.
  11. Cujic, I. Stefanoska and S. Golutbocis, "Serum ferritin in healthy women and breast cancer patients," J Med Biochem, vol. 30, pp. 33-37, 2011.
  12. Christ-Crain and S. Opal, "Clinical review: The role of biomarkers iin the diagnosis and management of community acquired pneumonia," Christ-Crain and Opal Critical Care, vol. 14, p. 203, 2010.
  13. Lorcerie, S. Audia, M. Samson and e. al., "Diagnosis of hyperferrritinemia in a routine clinical practice," Presse Med. , 2017.
  14. E. Nassir, "Detection of serum ferritin in women with breast cancer," Iraqi J Pharm Sci, vol. 25, no. 1, pp. 23-27, 2016.

Corresponding Author

Abdel Jawad Salim Salem

First Specialist in Family Medicine, Prince Hussein Hospital, Jordan