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Category: Volume 08 Issue 03 March 2020
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Title: Clinico-histopathological Study of Vesiculobullous Lesions of the Skin at Tertiary Care Centre

Authors: Shekhawat Pratibha, Yadav Ajay, Udawat Hema, Ranawat Chandrajeet Singh, Kotia Suman

 DOI: https://dx.doi.org/10.18535/jmscr/v8i3.122

Abstract

   

Introduction: Vesiculobullous eruptions are encountered in various dermatosis, which include various inflammatory, infective, autoimmune, drug induced as well as genetic. Primary lesion in vesiculobullous diseases is a vesicle or a bulla involving skin and/or mucous membrane.

Aim: To study the histomorphological features of various vesiculobullous disorders of skin with clinical correlation.

Materials and Methods: A laboratory based cross-sectional observational study was conducted over a period of 10 months from June 2018 to March 2019 in the Department of Pathology, S.M.S Medical College, Jaipur. 55 clinically diagnosed cases of vesiculobullous lesions of the skin included in the study.

Results: Out of 55 cases of vesiculobullous disorders Pemphigus vulgaris constituted the most common disease with 49.09% followed by Bullous pemphigoid 12.72%. Out of the 55 cases, 50 cases were clinically diagnosed as one of the varieties of vesiculobullous lesions, which were confirmed on histology.

Conclusion: Pemphigus vulgaris constituted the most common subtype of vesiculobullous disorder in this study followed by Bullous pemphigoid. Clinicopathological correlation is very important in the diagnosis of vesiculobullous disorders rather than considering either of them alone.

Keywords: Vesiculobullous disorders, Pemphigus vulgaris, Bullous pemphigoid.

References

  1. Murphy GF, Sellheyer K, Mihm MC Jr. The skin. In: Kumar V, Abbas AK, Fausto N, editors. Robbins and Cotran: Pathologic basis of disease, 7th Elsevier Saunders; 2005: 1227-71.
  2. Wu H, Brandling-Bennet HA, Harrist TJ. Noninfectious vesiculobullous and vesiculopustular diseases. In: Elder DE, Elenitsas R, Jaworky C, Johnson BL, Jr, editors. Lever’s histopathology of skin, 8th Lippincott Raven; 1997:209-45.
  3. Crosby DL, Diaz LA. Bullous disease: Introduction. Dermatol clin. 1993 July;11(3):373-8.
  4. Wojnarowska F, Venning VA, Fine JD, Burge SM. Immunobullous diseases and genetic blistering diseases. In: Burns T, Breathnach S, Cox N, Griffiths C, editors. Rook’s textbook of dermatology. 8th Caltron: Blackwell; 2010:40.3-40.19.
  5. Wu H, Brandling-Bennet HA, Harrist TJ. Noninfectious vesiculobullous and vesiculopustular diseases. In: Elder DE, Elenitsas R, Johnson BL,Jr, Murphy GF, Xu X, editors. Lever's histopathology of the skin. 10th Philadelphia, PA: Lippincott Williams and Wilkins; 2009:235-78.
  6. Arya SR, Valand AG, Krishna K. A clinico-pathological study of 70 cases of pemphigus. Indian J Dermatol Venereol Leprol. 1999; 65(4):168-71.
  7. Arundhathi S, Ragunatha S, Mahadeva KC. A cross-sectional study of clinical, histopatho-logical and direct immunofluorescence spectrum of vesiculobullous disorders. J Clin Diagn Res. 2013 Dec;7(12):2788–92.
  8. Pavithra P, Ragunatha S, Sreelatha R. A cross-sectional study of clinical and histopathological features of vesiculobullous skin lesions. Res J Pharm, Biol Chem Sci. 2014 May-Jun;5(3):849-55.
  9. Patel PR, Patel PB, Chiplonkar SG. Histopathological study of vesiculobullous lesions of the skin: a study at tertiary care hospital. Int J Med Sci Public Health. 2014;3(6):738-40.
  10. Krishnamurthy T, Shivarudrappa AS, Biligi DS, Shubhashree MN. Histopathological study of vesiculobullous lesions of skin. Int J Biol Med Res. 2015;6(2):4966-72.
  11. Punneshetty DS, Sulakshana MS, Manjunatha YA, Jayaprakash HT. A histomorphological study of bullous lesions of skin with special reference to immunofluorescence. Int J Curr Res Aca Rev. 2015 Mar;3(3):29-51.
  12. Kushtagi AV, Neeravari VS, Sidhalingreddy, Pratima S. Clinical and histopathological spectrum of vesciculobullous lesions of skin-a study of 40 cases. Indian J Pathol Oncol. 2016 Apr-Jun;3(2):152-8.
  13. Kudligi C, Thirunavukkarasu A, Kuntoji V, Bhagwat PV, Rathod R, Girian S, et al. Clinical and pathological study of autoimmune vesiculobullous disorders. J Pak Assoc Dermatol. 2017;27(3):270-8.
  14. Mittal H, Kaur S, Garg B, Sood N, Gupta SK, Kaur S. A study of clinicopathologic spectrum of vesicobullous disorders. Int J Res Dermatol. 2017 Sep;3(3):355-64.
  15. Karattuthazhathu AR, Vilasiniamma L, Poothiode U. A study of vesiculobullous lesions of skin. Nat J Lab Med. 2018 Jan;7 (1):PO01-6.
  16. Basu K, Chatterjee M, De A, Sengupta M, Datta C, Mitra P. A clinicopathological and immunofluorescence study of intraepidermal immunobullous diseases. Indian J Dermatol. 2019 Mar-Apr;64(2):101–5.

Corresponding Author

Yadav Ajay

Senior Professor, Department of Pathology, SMS Medical College, Jaipur, Rajasthan, India