Title: Correlations urinary N-acetyl-beta-D-glucosaminidase with proteinuria, SLEDAI-2K (renal), Anti ds DNA antibody titre and serum C3
Authors: Dr A. S. M. Julfekar Helal, Dr Md. Hafizur Rahman
DOI: https://dx.doi.org/10.18535/jmscr/v8i3.116
Abstract
Objective: In this study our main goal is to evaluate correlations urinary N-acetyl-beta-D-glucosaminidase with proteinuria, SLEDAI-2K (renal), Anti ds DNA antibody titre and serum C3.
Method: This cross-sectional prospective observational type of study was done among 60 Diagnosed lupus nephritis patients (active and inactive) at Department of Nephrology, Dhaka Medical College Hospital, Dhaka from January 2018 to December 2018. The informed written consent was taken from each patient.
Results: during the study, there was no significant difference in age between active and inactive lupus nephritis patients. Also, most of the patients in both groups were female and serum C3 were significantly lower in active LN than that of inactive LN. ESR, proteinuria, Anti ds DNA Ab titre and uNAG were significantly higher in active LN than that of inactive LN. Also, uNAG is more sensitive than Anti ds DNA antibody titre.
Conclusion: From our study we can conclude that, uNAG is a useful biomarker which had positive correlation with SLEDAI-2K (significantly), proteinuria, Anti ds DNA Ab titre. uNAG had negative correlation with serum C3. Further large-scale study should be carried out for reaching optimal goal. There is therefore a need for larger prospective studies in Bangladesh for diabetics to evaluate this as well as its cost effectiveness in resource poor-settings.
Keywords: urinary N-acetyl-beta- D-glycosaminidase, SLEDAI-2K (significantly), proteinuria, Anti ds DNA Ab titre.
References
- Renal Association–European Dialysis and Transplant Association (EULAR/ERA-EDTA) recommendations for the management of adult and paediatric lupus nephritis. Annals of the rheumatic diseases, pp.annrheumdis-2012.
- Bihl, G.R., Petri, M. and Fine, D.M., 2006. Kidney biopsy in lupus nephritis: look before you leap. Nephrology Dialysis Transplantation, 21(7), pp.1749-1752.
- Birmingham, D.J., Irshaid, F., Nagaraja, H.N., Zou, X., Tsao, B.P., Wu, H., Yu, C.Y., Hebert, L.A. and Rovin, B.H., 2010. The complex nature of serum C3 and C4 as biomarkers of lupus renal flare. Lupus, 19(11), pp.1272-1280.
- Birmingham, D.J., Irshaid, F., Nagaraja, H.N., Zou, X., Tsao, B.P., Wu, H., Yu, C.Y., Hebert, L.A. and Rovin, B.H., 2010. The complex nature of serum C3 and C4 as biomarkers of lupus renal flare. Lupus, 19(11), pp.1272-1280.
- Borchers, A.T., Leibushor, N., Naguwa, S.M., Cheema, G.S., Shoenfeld, Y. and Gershwin, M.E., 2012. Lupus nephritis: a critical review. Autoimmunity reviews, 12(2), pp.174-194.
- Bosomworth, M.P., Aparicio, S.R. and Hay, A.W., 1999. Urine N-acetyl-beta-D-glucosaminidase--a marker of tubular damage?. Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association-European Renal Association, 14(3), pp.620-626.
- Cai, X., Yang, X., Lian, F., Lin, X., Liang, M., Li, J., et al. 2010. Correlation between serum anti-C1q antibody levels and renal pathological characteristics and prognostic significance of anti-C1q antibody in lupus nephritis. The Journal of rheumatology, 37(4), pp.759-765.
- Cameron, J.S., 1999. Lupus nephritis. Journal of the American Society of Nephrology, 10(2), pp.413-424.
- Cervera, R., Khamashta, M.A., Font, J., Sebastiani, G.D., Gil, A., Lavilla, P., et al. 2003. Morbidity and mortality in systemic lupus erythematosus during a 10-year period: a comparison of early and late manifestations in a cohort of 1,000 patients. Medicine, 82(5), pp.299-308.
- Chen, D.Y., Chen, Y.M., Wen, M.C., Hsieh, T.Y., Hung, W.T. and Lan, J.L., 2012. The potential role of Th17 cells and Th17-related cytokines in the pathogenesis of lupus nephritis. Lupus, 21(13), pp.1385-1396.