Title: A Study on Etiological Agents and their Antimicrobial susceptibility causing Chronic Suppurative Otitis Media in a Tertiary Care Hospital

Authors: Dr Vrutika V. Gandhi, Dr M. Kalyani , Dr P. Neelu Sree , Dr B. Vivekanandan

 DOI: https://dx.doi.org/10.18535/jmscr/v8i3.80

Abstract

   

Chronic suppurative otitis media (CSOM) is the most common cause of hearing impairment in the developing countries and it is associated with increased incidence of intracranial and extra cranial complications. To isolate, identify and characterize the Bacterial organisms and detect the antibacterial susceptibility pattern of the isolates by using microbiological methods from specimens of clinically proved cases of chronic suppurative otitis media. A total of 245 patients with CSOM were studied. Swabs were collected from each patient and cultured for bacteria and fungus. Standard methods for isolation and identification of bacteria and fungus were followed. Antibiotic susceptibility testing was done by Kirby-Bauer’s disc diffusion method.  Out of the 245 samples studied for bacterial and fungal isolates, 225 samples showed growth of pathogens, 20 samples did not show any growth, 201 samples showed bacterial growth, The most predominant organism was Staphylococcus aureus, 24 samples showed fungal growth, Aspergillus sps being the predominant isolate. Antibiotic sensitivity of organism altered over time, with needs for periodic bacteriological examination. Staphylococcus aureus being most common organism isolated is highly sensitive to cloxacillin and cephelexin. Patients would be benefited by accurate diagnosis of type of infection and the appropriate drug that will be sensitive for the infection can be administered to them.

Keywords: Chronic Suppurative otitis media, bacterial and fungal isolates, Staphylococcus aureus, Aspergillus species.

References

  1. Aberg B, Westin T, Tjellstrom A, Edstrom S. Clinical characteristics of cholesteatoma. Am J Otolaryngol, 1991; 12:254–8.
  2. Vartianinen E. Changes in the clinical presentation of chronic otitis media from the 1970s to the 1990s. J Laryngol Otol 1998;112:1034–7
  3. Alho OP, Jokinen K, Laitakari K, Palokangas J. Chronic suppurative otitis media and cholesteatoma. Vanishing iseases among Western populations. Clin Otolaryngol. 1997; 22: 358–61.
  4. Maharjan M, Kafle P, Bista M, Shrestha S, KC Toran, Observation of hearing loss in patients with chronic suppurative otitis media tubotympanic type. Kathmandu University Medical Journal 2009, 7(28), 397-401.
  5. Srivastava V.K, Agarwal S.K,. Malik G.K, Chronic suppurative otitis media in children. Indian Med J.1979,46,363.
  6. Loy AH, Jan AL. Lu PK microbiology of chronic supparative otitis media in Singapore. Singapore Medical Journal 2002 Jun; 43(6) 296-9
  7. Sharma S, Rehan HS, Goyal A, Jha AK. Upadhyaya S. Misha SC, Bacteriological profile in chronic supportive otitis media in Eastren Nepal; Tropical Doctor 2004, 34(2): 102-4.
  8. Nikakhlagh S, Khossravi AD, Fazlipour A, Safarzadeh M, Microbiologic findings in patients with chronic suppurative otitis media, Med.Sci, 2008, 8(5); 503-506.
  9. Yang Y. Gong S. Liu Y. Clinical investigation of bacteriology of chronic supparative otitis media. Lin Chung Er Bi Yan Hou Ke Za Zh. 2001 Dec. 15 (17) 550-7.
  10. Sharma S, Rehan HS, Goyal A, Jha AK. Upadhyaya S. Misha SC, Bacteriological profile in chronic supportive otitis media in Eastren Nepal; Tropical Doctor 2004, 34(2): 102-4.
  11. Vikram BK, Khaja N, Udayashankar SG, Venkatesha BK, Manjunath D, Clinico epidemiological study of complicated and uncomplicated chronic suppurative otitis media, The Journal of Laryngology & Otology (2008), 122, 442–446.
  12. Mansoor T, Musani MA, Khalid G, Kamal M, Pseudomonas aeruginosa in chronic suppurative otitis media: sensitivity spectrum against various antibiotics in Karachi, J Ayub Med Coll Abbottabad 2009;21(2),120-123.
  13. Loy AH, Jan AL. Lu PK microbiology of chronic supparative otitis media in Singapore. Singapore Medical Journal 2002 Jun; 43(6) 296-9
  14. Jang CH & Park SY, Emergence of ciprofloxacin-resistant pseudomonas in chronic suppurative otitis media, Otolaryngol. 2004, 29, 321–323.
  15. Ibekwe AO, al Shareef Z, Benayam A. Anaerobes and fungi in chronic suppurative otitis media. Ann Otol Rhinol Laryngol 1997;106:649-52.
  16. Talwar P, Chakrabarti A, Kaur P, Pahwa RK, Mittal A, Mehra YN. Fungal infections of ear with special reference to chronic suppurative otitis media. Mycopathologia 1988;104:47.

Corresponding Author

Dr Vrutika V. Gandhi