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Category: Volume 08 Issue 03 March 2020
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Title: The Correlation of Serum Vitamin D and HDL Level with Disease Activity Score -28 In Patients of Rheumatoid Arthritis

Authors: Dr Cankatika Choudhury, Dr Partha Sarathi Karmakar, Dr Pradeep S

 DOI: https://dx.doi.org/10.18535/jmscr/v8i3.71

Abstract

   

Rheumatoid arthritis (RA) is the most common chronic symmetric polyarthritis characterized by erosive arthritis, joint destruction and a variety of extraarticular manifestations. Insights gained by a wealth of basic and clinical research over the past two decades have revolutionized the contemporary paradigms for the diagnosis and management of RA.A clinical state defined as low disease activity or remission is the optimal goal of therapy. Composite indices, such as the Disease Activity Score -28 or DAS28 is very useful in practise. Vitamin D has an immunomodulatory role in RA and its reduced intake is associated with increased disease activity. High inflammatory burden in RA contributes to cardiovascular morbidity and there’s reduced levels of High-Density Lipoprotein (HDL) cholesterol. Hence, Serum Vitamin D & HDL level can serve as useful markers of disease activity in RA.

References

  1. Sharif, K., Sharif, A., Jumah, F., Oskouian, R., & Tubbs, R. S. (2018). Rheumatoid arthritis in review: Clinical, anatomical, cellular and molecular points of view. Clinical Anatomy, 31(2), 216-223.
  2. Gavrilă, B. I., Ciofu, C., & Stoica, V. (2016). Biomarkers in rheumatoid arthritis, what is new? Journal of medicine and life, 9(2), 144.
  3. Cutolo, M., Otsa, K., Uprus, M., Paolino, S., & Seriolo, B. (2007). Vitamin D in rheumatoid arthritis. Autoimmunity reviews, 7(1), 59-64.
  4. Alemao, E., Guo, Z., Frits, M. L., Iannaccone, C. K., Shadick, N. A., & Weinblatt, M. E. (2018, April). Association of anti-cyclic citrullinated protein antibodies, erosions, and rheumatoid factor with disease activity and work productivity: A patient registry study. In Seminars in arthritis and rheumatism(Vol. 47, No. 5, pp. 630-638). WB Saunders.
  5. Meyer, P. W., Ally, M. M., & Anderson, R. (2016). Reliable and cost-effective serodiagnosis of rheumatoid arthritis. Rheumatology international, 36(6), 751-758.
  6. Fakhr, A., Hakim, F., Zaidi, S. K., Yusuf, R., & Sharif, A. (2017). Clinical registry for rheumatoid arthritis; a preliminary analysis. Pakistan Armed Forces Medical Journal, 67(2), 317-21.
  7. Ormseth, M. J., & Stein, C. M. (2016). HDL function in rheumatoid arthritis. Current opinion in lipidology, 27(1), 67.
  8. O'Dell, J. R., Haire, C., Erikson, N., Drymalski, W., Palmer, W., Maloley, P., ... & Moore, G. F. (1996). Efficacy of triple DMARD therapy in patients with RA with suboptimal response to methotrexate. The Journal of rheumatology. Supplement, 44, 72-74.
  9. Cash, J. M., & Klippel, J. H. (1994). Second-line drug therapy for rheumatoid arthritis. New England Journal of Medicine, 330(19), 1368-1375.
  10. Wilke, W. S., & Clough, J. D. (1991, October). Therapy for rheumatoid arthritis: combinations of disease-modifying drugs and new paradigms of treatment. In Seminars in arthritis and rheumatism(Vol. 21, No. 2, pp. 21-34). WB Saunders.
  11. Escalante, A., & Del Rincón, I. (1999). How much disability in rheumatoid arthritis is explained by rheumatoid arthritis? Arthritis & Rheumatism: Official Journal of the American College of Rheumatology, 42(8), 1712-1721.
  12. Escalante, A., & Del Rincón, I. (1999). How much disability in rheumatoid Neve, A., Corrado, A., & Cantatore, F. P. (2014)? Immunomodulatory effects of vitamin D in peripheral blood monocyte-derived macrophages from patients with rheumatoid arthritis. Clinical and experimental medicine, 14(3), 275-283.arthritis is explained by rheumatoid arthritis? Arthritis & Rheumatism: Official Journal of the American College of Rheumatology, 42(8), 1712-1721.
  13. Escalante, A., & Del Rincón, I. (1999). How much disability in rheumatoid arthritis is explained by rheumatoid arthritis? Arthritis & Rheumatism: Official Journal of the American College of Rheumatology, 42(8), 1712-1721.
  14. Song, G. G., Bae, S. C., & Lee, Y. H. (2012). Association between vitamin D intake and the risk of rheumatoid arthritis: a meta-analysis. Clinical rheumatology, 31(12), 1733-1739.
  15. Pelajo, C. F., Lopez-Benitez, J. M., & Miller, L. C. (2010). Vitamin D and autoimmune rheumatologic disorders. Autoimmunity reviews, 9(7), 507-510.
  16. Haque, U. J., & Bartlett, S. J. (2010). Relationships among vitamin D, disease activity, pain and disability in rheumatoid arthritis. Clin Exp Rheumatol, 28(5), 745-7.
  17. Neve, A., Corrado, A., & Cantatore, F. P. (2014). Immunomodulatory effects of vitamin D in peripheral blood monocyte-derived macrophages from patients with rheumatoid arthritis. Clinical and experimental medicine, 14(3), 275-283.
  18. Mateen, S., Moin, S., Shahzad, S., & Khan, A. Q. (2017). Level of inflammatory cytokines in rheumatoid arthritis patients: Correlation with 25-hydroxy vitamin D and reactive oxygen species. PloS one, 12(6).
  19. Mikuls, T. R., Saag, K. G., Criswell, L. A., Merlino, L. A., Kaslow, R. A., Shelton, B. J., & Cerhan, J. R. (2002). Mortality risk associated with rheumatoid arthritis in a prospective cohort of older women: results from the Iowa Women’s Health Study. Annals of the rheumatic diseases, 61(11), 994-999.
  20. Merlino, L. A., Curtis, J., Mikuls, T. R., Cerhan, J. R., Criswell, L. A., & Saag, K. G. (2004). Vitamin D intake is inversely associated with rheumaLazarevic, M. B., Vitic, J., Mladenovic, V., Myones, B. L., Skosey, J. L., & Swedler, W. I. (1992, December). Dyslipoproteinemia in the course of active rheumatoid arthritis. In Seminars in arthritis and rheumatism(Vol. 22, No. 3, pp. 172-180). WB Saunders.toid arthritis: results from the Iowa Women's Health Study. Arthritis & Rheumatism: Official Journal of the American College of Rheumatology, 50(1), 72-77.
  21. Patel, S., Farragher, T., Berry, J., Bunn, D., Silman, A., & Symmons, D. (2007). Association between serum vitamin D metabolite levels and disease activity in patients with early inflammatory polyarthritis. Arthritis & Rheumatism: Official Journal of the American College of Rheumatology, 56(7), 2143-2149.
  22. Hong, Q., Jianhua, X. U., Shengqian, X. U., Zhang, R., Zhang, M., & Zou, Y. (2013). Changes and clinical significance of serum 25-hydroxy-vitamin D levels in rheumatoid arthritis. Chinese Journal of Rheumatology, (3), 159-163.
  23. Bag-Ozbek, A., & Giles, J. T. (2015). Inflammation, adiposity, and atherogenic dyslipidemia in rheumatoid arthritis: is there a paradoxical relationship? Current allergy and asthma reports, 15(2), 497.
  24. Davidson, W. S., Silva, R. G. D., Chantepie, S., Lagor, W. R., Chapman, M. J., & Kontush, A. (2009). Proteomic analysis of defined HDL subpopulations reveals particle-specific protein clusters: relevance to antioxidative function. Arteriosclerosis, thrombosis, and vascular biology, 29(6), 870-876.
  25. Ormseth, M. J., & Stein, C. M. (2016). HDL function in rheumatoid arthritis. Current opinion in lipidology, 27(1), 67.
  26. Lazarevic, M. B., Vitic, J., Mladenovic, V., Myones, B. L., Skosey, J. L., & Swedler, W. I. (1992, December). Dyslipoproteinemia in the course of active rheumatoid arthritis. In Seminars in arthritis and rheumatism(Vol. 22, No. 3, pp. 172-180). WB Saunders.
  27. Park, Y. B., Choi, H. K., Kim, M. Y., Lee, W. K., Song, J., Kim, D. K., & Lee, S. K. (2002). Effects of antirheumatic therapy on serum lipid levels in patients with rheumatoid arthritis: a prospective study. The American journal of medicine, 113(3), 188-193.
  28. Chung, C.P., Oeser, A., Raggi, P., Gebretsadik, T., Shintani, A.K., Sokka, T., Pincus, T., Avalos, I. and Stein, C.M., (2005). Increased coronary‐artery atherosclerosis in rheumatoid arthritis: relationship to disease duration and cardiovascular risk factors. Arthritis & Rheumatism: Official Journal of the American College of Rheumatology, 52(10), 3045-3053.

Corresponding Author

Dr Cankatika Choudhury

MD, Department of Medicine, R.G. Kar Medical College & Hospital, Kolkata