Title: To study the association of sudden sensorineural hearing loss and mean platelet volume including other platelet parameters within an Indian population
Authors: Ibadaiamon Mawroh, Kanwar Sen, Sadhna Marwah
DOI: https://dx.doi.org/10.18535/jmscr/v8i3.70
Abstract
Objective: In this study, we aim to determine whether patients with sudden SNHL in North India, had an elevated Mean platelet volume (MPV), platelet count (PC) and platelet distribution width (PDW).
Study Design: Cross- sectional observation study
Setting: PGIMER, Dr Ram Manohar Lohia Hospital, New Delhi
Subjects and Methods: In this study, a group of 30 patients and 30 healthy subjects were taken as controls. Blood samples were drawn immediately on admission. The platelet parameters were analysed in the Medonic M series haematology cell counter. Comparisons of the blood indices were made between the two groups. Quantitative variables were compared using Unpaired t-test /Mann Whitney test (when data sets were not normally distributed) between the two groups.
Qualitative variables were correlated using Chi Square test/Fischer’s exact test. A p value of < 0.05 was considered statistically significant.
Results: Although the MPV, PDW and PC were marginally higher in the cases compared to the control group, a significant difference (p< 0.05) was not observed between the two groups. The mean platelet volume showed a p value of 0.197, the platelet count had a p value of 0.433 and the platelet distribution width revealed a p value of 0.67.
Conclusion: Hence, the mean platelet volume and other platelet parameters are not associating factors in the occurrence of sudden sensorineural hearing loss.
Keywords: Mean platelet volume, platelet parameters, sudden sensorineural hearing loss.
References
- Anderson RG, Meyerhoff WL. Sudden sensory neural hearing loss. Otolaryngol Clin North Am.1983; 16:189-194
- Park SN, Yeo SW, Park KH. Serum heat shock proteins 70 and its co-relation with clinical characteristics in patients with sudden sensorineural hearing loss. Laryngoscope. 2006; 116: 121-125
- M Sagit, M Kavugudurmaz,S Guller,M M Somdas. The journal of laryngology and otology. 2013; 127:972-976
- Cappacio P, Ottariani F, Cuccarini V, Bottero A, Schindler A, Cesana BM, Censuales S, Pignataro L. Genetic and acquired prothrombotic risk factors and sudden hearing loss. Laryngoscope.2007; 117:547-551
- Park Y,Schoene N, Harris W. Mean platelet volume as an indicator of platelet activation. Methodological isssues. Platelets. 2002;13: 301-6
- Gasparyan AY, Avvazyan L, Mikhalidis DP, Kitas GD. Mean platelet volume; A link between thrombosis and inflammation? Curr Pharm Des. 2011; 17910:47-58
- Yildiz Z, Ulu A, Incesulu A, Ozkaptan Y, Akar N. The importance of thrombotic risk factors in the development of idiopathis sudden sensorineural hearing loss. Clin Appl Thromb Hemost 2008.Jul; 14(3): 356-9
- Zajtchuk JT, Falor WH Jr, Rhodes MF.Hypercoagulability as a cause of sudden neurosensory hearing loss. Otolaryngol Head Neck Surg. 1979; 87: 268-273
- Bomholt A, Bak Pederson K, Gormsen J. Fibrinolytic activity in patients with sudden sensorineural hearing loss. Acta Otolaryngol Suppl Stockh. 1979; 360:184-186
- Owen MC, Borg JY, Soria J, Caen J, Carell RW. Heparin binding defect in a new antithrombin III variant. Rouen 47, Arg to His Blood. 1987;69: 1275-1279
- Jaffe BF.Hypercoagulation and other causes of sensorineural hearing loss. Otolaryngol Clin North Am. 1975; 8: 395-403
- Gold S, Kamerer DB, Hirsch BE, Cass SP. Hypercoagulability in otologic patients. Am J Otolaryngol. 1993; 327-331
- Hudges GB, Fredman MA, Haberkamp TJ, Guay ME. Sudden sensorineural hearing loss.Otolaryngol in North Am. 1996; 29:236-405
- Einer H,Tengborn L, Axelsson A, Edstrom S. Sudden sensorineural hearing loss. Otolaryngol Head Neck Surg. 1994; 120: 536-40
- Karli R, Alacam H, Unal R, Kucuk H, Aksoy A, Ayhan E. Mean platelet volume: is it a predictive parameter in the diagnosis of sudden sensorineural hearing loss? Indian J Otolaryngol Head Neck Surg. 2013; 65(4): 350-3.