Title: Cross-sectional study to compare the clinical features in low normal versus high normal plasma glucose levels in euglycemic individuals

Authors: Dr Vinod Verma, Dr Dharmendra Jhavar, Dr Umesh Kumar Chandra

 DOI: https://dx.doi.org/10.18535/jmscr/v8i3.37

Abstract

   

Introduction: It has been known that the diagnosis of diabetes should be made early to prevent cardiovascular and other metabolic complications. So far, determination of blood glucose levels has been used to diagnose diabetes. It shows why the glucose-centric definition for diagnosing diabetes that has been used so far could not be applied to the sole diagnosis criteria for a group of patients with such “syndrome”.

Materials and Methods: This cross sectional study was carried out in the department of medicine, M.G.M. Medical College and M.Y. Hospital Indore from July 2016 to August 2017 in 200 individuals and patients having euglycemic status attending General Medicine OPD.

Results: The mean BMI in the low normal group was 23.79±1.09 kg/m2 and in the high normal group it was 24.43±1.26 kg/m2. The difference was found to be statistically significant (P<0.05). In the low normal group, of the females, 40(80%) were having normal W:H ratio and 10(20%) were having abnormal W:H ratio. In males, only 5(10%) were having abnormal W:H ratio. In the high normal group, in females 15(33.3%) were having abnormal W:H ratio. In males, 19(34.5%) were having abnormal W:H ratio. In 100(100%) patients of both the groups, the fundus findings were found to be normal.

Conclusions: It can be concluded that higher values of BMI, Waist-Hip Ratio and positive family history for diabetes were found more commonly associated with high normal euglycemic group when compared with low normal euglycemic group. 

Keywords: Body Mass Index, Euglycemia, Waist Hip Ratio.

References

  1. Rushforth NB, Miller M, Bennett PH. Fasting and two-hour post-load glucose levels for the diagnosis of diabetes: the relationship between glucose levels and complications of diabetes in the Pima Indians. Diabetol. 1979;16:373-9.
  2. National Diabetes Data Group. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes. 1979;28:1039-57.
  3. Jarrett RJ, Keen H. Hyperglycaemia and diabetes mellitus. Lancet. 1976;1:1009-11.
  4. Sayegh HAI, Jarrett RJ. Oral glucose tolerance tests and the diagnosis of diabetes: results of a prospective study based on the Whitehalll Survey. Lancet. 1979;2:431-3.
  5. Pettitt DJ,Knowler WC, Lisse, Bennett PH. Development of retinopathy and proteinuria in relation to plasma-glucose consentrations in Pima Indians. Lancet. 1980;2:1050-2.
  6. Dale AC, Vatten LJ, Nilsen TI, Midthjell K, Wiseth R. Secular decline in mortality from coronary heart disease in adults with diabetes mellitus: cohort study. Br Med J 2008; 337:236.
  7. Libby P. Current concepts of the pathogenesis of the acute coronary syndromes. Circulation 2001; 104: 365–372.

Corresponding Author

Dr Dharmendra Jhavar

Professor, Department of Medicine, MGM Medical College and MY Hospital, Indore, MP, India