Title: Plain Film Radiography and Magnetic Resonance Imaging in Degenerative Disease of Spine: A Comparative Study

Authors: Naresh Chandra Yadav, Ashok Kumar Verma, Rakesh Kumar Verma, Rashmi

 DOI: https://dx.doi.org/10.18535/jmscr/v8i3.34

Abstract

   

Degenerative disease of spine is a definition that includes a wide spectrum of degenerative abnormalities. Degeneration involves bony structure, ligaments, facet joints and intervertebral disc. During life the spine undergoes continuous changes as a response to physiologic axial load, these age related changes are similar to pathologic degenerative changes and are common asymptomatic finding in adults and elderly persons. Imaging allows complete evaluation of static and dynamic factors related to degenerative disease of spine and is useful in diagnosing the different aspects of spine degeneration. The present cross sectional study is intended to compare and correlate the finding of plain film radiography with that of MRI in degenerative diseases of spine to enable early diagnosis. A total of 60 patients complained of back pain and/or patients with neurologic complaints such as tingling sensations, numbness weakness referred pain in limbs were included in the study. The current study found that percentage of the male patients was 58.33% and of female was 41.7% showing a slight male preponderance for degenerative spine disease. The mean age of incidence in our study was 43.65 years. The youngest and the oldest patients were 24 years and 79 years respectively. The most of the patients were in 40-50 years age group (25%). Lower back pain was the most common feature (70%) followed by radiating pain (55%), followed by tingling and numbness (26.6%) and cervical pain (25%). 13 patients out of 30 (43%) patients above 50 years of age had generalized involvement on plain film as compared to 24 out of 30 (80%) patients on MRI. On plain film, osteophytes were seen in 66% patients and on MRI in 55% patients. Lumbar spine was the commonest region of involvement on both imaging followed by cervical region. Commonest level of spinal canal stenosis was L4/L5 on both plain film and MRI seen in 15 and 24 patients respectively. Plain film showed facet joint arthrosis in 45% patients and on MRI it was seen in 63% patients with commonest level being L4/L5 on both the imaging techniques. Prevalence of neural foraminal obliteration and spinal canal stenosis were significantly higher on MRI as compared to plain film. Plain film is the basic modality which can be used as a baseline imaging. In a symptomatic patient who has failed non operative conservative treatment and has normal X-ray findings, an MRI can be a very useful tool for further evaluation.

Keywords: Spine, Disc bulge, Degenerative disease, Facet joint, Intervertebral disc, Canal stenosis, MRI.

References

  1. Damkot DK, Pope MH, Lord J, Fryomer JW. The relationship between work history, work environment and low back pain in men. Spine 1984; 9:395-9.
  2. Kieffer SA, Sherry RG, Wellenstein DE, King RB. Bulging lumbar intervertebral disk: myelographic differentiation from herniated disk with nerve root compression. Am J Roentgenol. 1982; 138 (4):709-16.
  3. Modic MT, Pavlicek W, Weinstein MA, Boumphrey F, Ngo F, Hardy R, Duchesneau PM. Magnetic resonance imaging of intervertebral disc disease. Radiology. 1984;152(1):103-11.
  4. Frymoyer JW, Newberg S, Pope MH, Wilder DG, Clements J, MacPherson B. Imaging of degenerative disc disease. J Bone Joint Surg Am. 1984;66:1048-55.
  5. Gibson MJ, Buckley J, Mawhinney R, Mulholland RC, Worthington BS, Magnetic resonance imaging and discography in the diagnosis of disc degeneration. J Bone Joint Surg. 1986;68(3):369-73.
  6. Michele T. Modic, Peter M. Steinberg, Jeffrey S. Ross, Thomos J. Masaryk, John R. Carter. Degenerative disc disease: Assessment of changes in vertebral body marrow with imaging. Radiology 1988; 166:193-9
  7. Ho PS, Yu SW, Sether LA, Wagner M, Ho KC, Haughton VM. Ligamentum flavum: appearance on sagittal and coronal MR images. Radiology.1988;168(2):469-72.
  8. Rubin JB,Wright A, Enzmann DR. Lumbar Spine: motion compensation for cerebrospinal fluid on MR imaging. Radiology 1988;167:225-31.
  9. Saifuddin A, Braithwaite I, White J, Taylor BA. The value of lumbar spine magnetic resonance imaging in the demonstration of annular tears. Spine.1988;23(4):453-457.
  10. Boden SD, Davis DO, Dina TS, Patronas NJ, Wiesel SW. Abnormal magnetic resonance scans of the lumbar spine in asymptomatic subjects. A prospective investigation. J Bone Joint Surg Am.1990;72:403-8.
  11. Sether LA, Shiwei Yu, Haughton VM, Fischer ME. Intervertebral disc: normal age changes in MR signal intensity. Radiology. 1990;177:385-8.
  12. Jensen MC, Brant-Zawadzki MN, Obuchowski N, Modic MT, Malkasian D et al. Magnetic resonance imaging of the lumbar spine in people without back pain. The New England Journal of Medicine.1994;33 1:69-73.
  13. Jensen ME. Lumbar herniated disc disease; Comparison of MRI, myelography, and post-myelographic CT scan with related surgical findings. Orthopedics. 1994;17: 121-7.
  14. Maureen C. Jensen, Michael N. Brant- Zawadzki, Nancy Obuchowski, Michael T. Modic, Dennis Malkasian et al. Magnetic resonance imaging of the lumbar spine in people without back pain. The New England Journal of Medicine. 1994; 331: 69-73
  15. Pople I K, Griffith HB. Prediction of an extruded fragment in lumbar disc patients from clinical presentations. Spine 1994; 19:156-8.
  16. Toyone, K. Takahashi, H. Kitahara, M. Yamagata, M. Mukarami, H. Moriya. Vertebral bone marrow changes in degenerative lumbar disc disease. J Bone Joint. 1994;76-B: 757-64.
  17. Carragee EJ, Kim DH.A prospective analysis of magnetic resonance imaging findings in patients with sciatica and lumbar disc herniation. Correlation of outcomes with disc fragment and canal morphology. Spine 1997;22(14):1650-60.
  18. Beattie PF, Meyers SP, Stratford P, Millard RW, Hollenberg GM. Associations between patient report of symptoms and anatomic impairment visible on lumbar magnetic resonance imaging. Spine 2000;25(7):819-28.
  19. Jeffrey G. Jarvik, Richard A. Deyo. Imaging of lumbar intervertebral disc degeneration and aging, excluding disc herniations. Radiological Clinics of North America 2000;38:1255-66.
  20. Vroomen PC de Krom M, Knottnerus JA. Consistency of history examination in patients with suspected lumbar nerve root involvement. Spine 2000;25: 91-7.
  21. Jarvik J, Hollingworth W, Heagerty P, David R. Haynor and Richard A. Deyo. The longitudinal assessment of imaging and disability of the back (LAID Back) study. Spine 2001;26: 1158-66.
  22. Montazel JL, Divine M, LepageE, Kobeiter H, Breil S, Rahmouni A. Normal spinal bone marrow in adults, Dynamic gadolinium-enhanced MR imaging. Radiology 2003;13:105-6.
  23. Murrie VIL, Dixon AK, Hollingworth W, Wilson H, Doyle TAC. Lumbar lordosis: Study of patients with and without low back pain. Journal of Clinical Anatomy. 2003;16(2): 144-7.
  24. Urban PG Jill, Sally Roberts. Degeneration of the intervertebral disc. Arthritis Res Ther. 2003; 5/3):120-130.
  25. Ong, J Anderson, J Roche. A pilot study of the prevalence of lumbar disc degeneration in elite athletes with lower back pain at the Sydney 2000 Olympic Games. Br J Sports Med 2003;37(3):263-6
  26. Pye SR, Reid DM, Smith R, Adams JE, Nelson K, Silman AJ. O Neil TW. Radiographic features of lumbar disc degeneration and self reported back pain. J Rheumatol. 2004; 31(4):753-8.
  27. Lebkowski WJ, Lebkowska U, Niedzwiecka M, Dzieciol J. The radiological symptoms of lumbar disc herniation and degenerative changes of the lumbar intervertebral discs. Med Sci Monit. 2004 Jun, 10 Suppl 3:112-4.
  28. Kjaer P, Leboeuf-Yde C, Korsholm L, Sorensen JS, Bendix T. Magnetic resonance imaging and low back pain in adults: a diagnostic imaging study of 40 year old men and women. Spine 2005;30:1173-80.
  29. Jong Beom Park, Jin Kyung Lee, Sung-Jin Park and K Daniel Riew. Hypertrophy of ligamentum flavum in lumbar spinal stenosis associated with increased proteinase inhibitor concentration. J Bone Joint Surg (Am) 2005;87:2750-7.
  30. Jayakumar P, Nnadi C, Saifuddin A, et al. Dynamic degenerative lumbar spondylolisthesis: diagnosis with axial loaded magnetic resonance imaging. Spine. 2006;31:298-301.
  31. Dahnet Wolfgang. Radiology Review Manual 2007 Lippincott Williams and Wilkins. Philadelphia, Pennsylvania. Central Nervous System. Disc degenerative disease. 2007;6:202-24.
  32. Kasdan RB, Howard JL. Neuroimaging of spinal diseases: a pictorial review. Seminars I neurology.2008 Sep; 28(4): 570-89.
  33. Takatalo J, Karppinen J, Niinimaki J, Taimela S, Nayha S, Jarvelin MR, Kyllonen E, Tervonen O, 2009 Prevalence of degenerative imaging findings in lumbar magnetic resonance imaging among young adults. Spine 2009 July;34(16): 1 716-21
  34. Kuisma M, Karppinen J, Haapea M, Niinimäki J, Ojala R, Heliövaara M, Korpelainen R, KailkkonenK, Taimela S, Natri A, Tervonen O. Are the determinants of vertebral endplate changes and severe disc degeneration in the lumbar spine the same? A magnetic resonance imaging study in middle-aged male workers Joint Bone Radiology 2009 Jul;76(4):361-8.
  35. Kuisma M, KarPpinen J, Haapea M, Lammentausta E, Niinimäki J, Tervonen O. Modic changes in vertebra endplates: a comparison of MR imaging and multislice CT. Skeletal Radiol, 2009 Feb,38(2):141-7.
  36. Cheung KM, Karppinen J, Chan D. Prevalence and pattern of lumbar magnetic resonance imaging changes in a population study of one thousand forty-three individuals. Spine 2009;34(9):934-40
  37. Igbinedion BOE, Akhibe E. Correlations of Radiographic findings in patient with low back pain. Niger Med J.2011; 52(1):28-34.
  38. Dominik Weishaupt, MD, Marco Zanetti, MD, JuergHodler, MD, Kan Min, MD, Bruno Fuchs, MD, Christian W. A. Pfirrmann, MD and Norbert Boos, MD. Painful Lumbar Disc Derangement: Relevance of Endplate Abnormalities at MR Imaging. Radiology, 2001; 218, 420-7.
  39. Gilbert J, Grant AM, Gillan MG, Vale LD, Campbell MK, Scott NW et al. Low Back Pain: Inluence of early MR imaging or CT treatment and outcome- multicenter Randomized trial. Radiology 2004;231: 342-5 1.
  40. Birla R, Singh A, Kharat A, Phalke U. A Role of contrast enhanced MRI in diagnosis of sequestered disc. IJRI, 2005;15(4): 489-91.
  41. Van Rijn J C, Klemetso N, Reitsma JB. Observer variation in the evaluation of lumbar herniated discs and root compression: spiral CT compared with MRI. British Journal of Radiology. 2006;79:372-7.
  42. Aithala P Janardhana, Rajagopal, Sharath Rao, Asha Kamath. Correlation between clinical features and MRI findings in lumbar disc prolapse. Indian J Orthop. 20 10;44 (3): 263-9.
  43. Eguchi Y, Ohtori S, Yamashita M, Yamauchik. Diffusion weighted magnetic resonance imaging to differentiate degenerative from infectious endplate abnormalities in lumbar spine. Spine. 2011;36(3):198-202.
  44. Teresi LM, Lufkin RB, Reicher MA, Moffit BJ, Vinuela FV, Wilson GM, Bentson JR, Hanafee WN, Asymptomatic degenerative disc disease and spondylosis of cervical spine: MR imaging. Radiology. 1987 Jul; 164(1):83-8.
  45. Luoma K, Riihimaki H, Luukkonen R, Raininko R, Viikari-Juntura E, Lamnminen A. Low back pain in relation to lumbar disc degeneration. Spine. 2000; 25(4):487-92.
  46. Adams MA , Freeman BJ, Morrison HP, Nelson IW, Dolan P. Mechanical initiation of intervertebral disc degeneration. Spine 2000; 25: 1625-36.
  47. Maniadakis N, Gray A. The economic burden of back pain in the UK. Pain. 2000;84:95-103.
  48. Borenstein G. David, James W. O'Mara, Scott D. Boden, William C. Lauerman, Alan Jacobson, Craig Platenberg, Dieter Schellinger, Sam W. Wiesel. The Value of Magnetic Resonance Imaging of the Lumbar Spine to Predict Low-Back Pain in Asymptomatic Subjects: A Seven-Year Follow-up Study. J Bone Joint Surg Am. 2001;83:1306-11.
  49. Urban PG Jill, Sally Roberts. Degeneration of the intervertebral disc. Arthritiss Res Ther.2003;5(3):120-30.
  50. Siddiqui AH, Rafique MZ, Ahmad MN, Usman MU. Role of magnetic resonance imaging in lumbar spondylosis. J Coll Physicians Surg Pak. 2005Jul; 15(7):396-9.
  51. Modic T. Michael, Nancy A. Obuchowski, Jeffery S. Ross, Michael N. Brant-Zawadzki, Paul N. Grooff, Daniel J. Mazanec, Edward C. Benzel. Acute Low Back Pain and Radiculopathy: MR Imaging Findings and Their Prognostic Role and Effect on Outcome. Radiology, 2005;237:597-604.
  52. Modic T. Michael, Jeffrey S. Ross. Lumbar Degenerative Disc Disease. Radiology 2007;245:43-61.
  53. Waris E, Eskelin M, Hermunen H, Kiviluoto O, Paajenan H. Disc degeneration in low back pain: a 17-year follow-up study using magnetic resonance imaging. Spine 2007 Mar 15, 32(6):681-4.
  54. Chenyang Wang BS, Joshua D, Auerbach Walter R.T, Witschey BS, Richard A. Advances in Magnetic Resonance for assessment of degenerative disc disease of the lumbar spine. Semin Spine Surg. 2007;19(2): 65-71.
  55. Khai S. LamMRI follow-up of subchondral signal abnormalities in a selected group of chronic low back pain patients. Eur Spine J 2008;17:1309-10.
  56. Albert HB, Kjaer P, Jensen TS, Sorensen JS, Bendix T, Manniche C. Modic changes, possible causes and relation to low back pain. Med Hypotheses. 2008;70(2):361-8.
  57. Thome C, Borm W, Meyer F. Degenerative lumbar spinal stenosis: current strategies in diagnosis and treatment. Dtsch Arztebl May;105 (20):373-9.
  58. Kasdan RB, Howard JL. Neuroimaging of spinal diseases: a pictorial review. Semin Neurol. 2008 Sep:28(4):570-89.
  59. Shobeiri E, Khalatbari MR, Taheri MS, Tofighirad N, Moharamzad Y. Magnetic Resonance imaging characteristics of patients with low back pain and those with sciatica. Singapore medical journal. 2009 Jan; 50(1):87-93.
  60. Lateef Humaira, Deepak Patel. What is the role of imaging in acute low back pain. Curr Rev Musculoskelet Med. 2009 June; 2(2): 69-73.

Corresponding Author

Dr Ashok Kumar Verma

Assistant Professor, Department of Radiodiagnosis, G.S.V.M Medical College, Kanpur, Uttar Pradesh