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Category: Volume 08 Issue 03 March 2020
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Title: The assessment of the occurrence of metabolic syndrome among postmenopausal women

Authors: Dr Shwetha B.M., Dr Sharath Kumar D Shah, Dr Muddarangappa R, Dr Annee Vylene Lyngdoh

 DOI: https://dx.doi.org/10.18535/jmscr/v8i3.12

Abstract

   

Background: The menopausal state may be a potential risk factor for the development of metabolic Syndrome as its prevalence has been reported to increase after the attainment of menopause 1. Metabolic Syndrome (MS) has been demonstrated as a common precursor to the development of diabetes and cardiovascular disease (CVD) as well as a risk factor for all cause mortality. Therefore to prevent cardiovascular diseases there is a need to evaluate the occurrence of metabolic Syndrome and its components from the time of the menopause.

Aims and Objectives: To determine the frequency of metabolic Syndrome in postmenopausal women and to evaluate the components of metabolic Syndrome in post menopausal women.

Methods: All data for the proposed descriptive study was collected from the patients presenting to the Department of General Medicine, Sri Siddhartha Medical College Hospital & Research centre, Tumkur. Post menopausal women who had at least 1 year history of cessation of menses were included. clinical examination, anthropometry and other investigations (Body height, Body weight, Waist circumference (WC), Body Mass Index(BMI), Lipid profile, Fasting blood sugar, Blood pressure were done. Post Menopausal women were considered to have Metabolic Syndrome (MS) if they have any three or more of the features according to the modified ATP III Criteria.

Results: Metabolic Syndrome was present in 62.5% of postmenopausal women and was absent in 37.5% of post menopausal women. Abdominal obesity (68.3%) was the most prevalent component of metabolic Syndrome followed by low HDL(53.8%), high BP(51%), hypertriglyceridemia (44.2%) and abnormal FBS (39.4%). Waist circumference, FBS,BP, triglycerides were significantly higher and HDL was significantly lower in postmenopausal women with metabolic Syndrome. Maximum correlation of MS was found with FBS (odds ratio ‑11.56) and least correlation was found with blood pressure (odds ratio ‑2.679).

Conclusion: The prevalence of metabolic Syndrome was high in our study. The components of metabolic Syndrome such as waist circumference, FBS, blood pressure, triglycerides were significantly raised and HDL levels were significantly reduced in post menopausal women with metabolic Syndrome. Such a high prevalence of metabolic Syndrome in postmenopausal women is an alarming sign. Lifestyle changes, early detection and treatment of elevated fasting blood glucose, hypertension and hyperlipidemia are necessary for prevention of cardiovascular diseases in women reaching menopause.

Keywords: metabolic Syndrome, menopause.

References

  1. Petri Nahas EA, Padoani NP, Nahas-Neto J, Orsatti FL, Tardivo AP, Dias R. Metabolic syndrome and its associated risk factors in Brazilian postmenopausal women. Climacteric J Int Menopause Soc. 2009 Oct;12(5):431-8
  2. Miranda PJ, De Fronzo RA, Califf RM, Guyton JR. Metabolic Syndrome: definition, pathophysiology, and mechanisms. American Heart Journal. 2005 149(1):33–45.
  3. Mesch VR, Boero LE, Siseles NO, Royer M, Prada M, Sayegh F, et al. Metabolic syndrome throughout the menopausal transition: influence of age and menopausal status. Climacteric. 2006;9(1):40-8.
  4. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC Jr. et al.Diagnosis and management of the metabolic Syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. 2005;112:2735–2752
  5. Jayasheela K, Ebenezer D, Vaibhav L, Thomas V, Bijesh Y, Kekre A. Prevalence of metabolic Syndrome among postmenopausal women in South India. Int J Reprod Contracept Obstet Gynecol. 2018 Jun;7(6):2364-2370
  6. Jouyandeh Z, Nayebzadeh F, Qorbani M, Asadi M. Metabolic syndrome and menopause. Journal of diabetes and metabolic disorders. 2013 Jan 3;12:1.
  7. Pandey S, Srinivas M, Agashe S, Joshi J, Galvankar P, Prakasam CP et al. Menopause and metabolic Syndrome: A study of 498 urban women from western India.J Midlife Health. 2010 Jul-Dec; 1(2): 63–69
  8. Sharma S, Aggarwal N, Joshi B, Suri V, Badada S. Prevalence of metabolic Syndrome in pre- and postmenopausal women: A prospective study from apex institute of North India. J Mid-life Health 2016; 7:169-74.
  9. Heidari R, Sadeghi M, Talaei M, Rabiei K, Mohammadifard N, Sarrafzadegan N. Metabolic syndrome in menopausal transition: Isfahan Healthy Heart Program, a population based study. Diabetol Metab Syndr 2010;2:59
  10. Figueiredo Neto JA, Figuerêdo ED, Barbosa JB, Barbosa Fde F, Costa GR, Nina VJ, et al. Metabolic syndrome and menopause: Cross-sectional study in gynecology clinic. Arq Bras Cardiol 2010;95:339-45
  11. Marjani A, Moghasemi S. The Metabolic Syndrome among Postmenopausal Women in Gorgan. Int J Endocrinol. 2012; 2012:953627.
  12. Tandon VR, Mahajan A, Sharma S, Sharma A. Prevalence of cardiovascular risk factors in postmenopausal women: A rural study. J Mid life Health 2010;1:26-9
  13. Janssen I, Powell LH, Crawford S, Lasley B, Sutton-Tyrrell K. Menopause and the metabolic Syndrome: The Study of Women's Health Across the Nation. Arch Intern Med 2008;168:1568-75
  14. Ruan X, Jin J, Hua L, Liu Y, Wang J, Liu S. The prevalence of metabolic Syndrome in Chinese postmenopausal women and the optimum body composition indices to predict it. Menopause 2010;17:566-70
  15. Jesmin S, Islam AS, Akter S, Islam MM, Sultana SN, Yamaguchi N, et al. Metabolic Syndrome among pre- and postmenopausal rural women in Bangladesh: result from a population-based study. BMC Res Notes. 2013 Dec;6(1):157.

Corresponding Author

Dr Shwetha B.M.

Junior Resident, Department of General Medicine, Sri Siddhartha Medical College Hospital & Research Centre, Tumakuru, Karnataka, India